Hit identification against peptidyl-prolyl isomerase of Theileria annulata by combined virtual high-throughput screening and molecular dynamics simulation approach
Sign Up to like & getrecommendations! Published in 2020 at "Computational biology and chemistry"
DOI: 10.1016/j.compbiolchem.2020.107398
Abstract: Theileria annulata secretes peptidyl prolyl isomerase enzyme (TaPIN1) to manipulate the host cell oncogenic signaling pathway by disrupting the tumor suppressor F-box and WD repeat domain-containing 7 (FBW7) protein level leading to an increased level… read more here.
Keywords: molecular dynamics; theileria annulata; peptidyl prolyl; compound ... See more keywords
Peptidyl‐prolyl cis‐trans isomerase A – A novel biomarker of multi‐episodic (recurrent) ocular toxoplasmosis☆
Sign Up to like & getrecommendations! Published in 2018 at "Experimental Eye Research"
DOI: 10.1016/j.exer.2018.07.029
Abstract: &NA; Ocular toxoplasmosis (OT) is the most common etiology of posterior uveitis. The high incidence of macular scarring associated with OT is a leading cause of visual morbidity. Serum biomarkers of the disease would aid… read more here.
Keywords: prolyl cis; biomarker; peptidyl prolyl; toxoplasmosis ... See more keywords
Peptidyl-prolyl isomerase and the biological activities of recombinant protein cyclophilin from Pyropia yezoensis (PyCyp).
Sign Up to like & getrecommendations! Published in 2020 at "Protein expression and purification"
DOI: 10.1016/j.pep.2020.105636
Abstract: Cyclophilins are highly conserved proteins associated with peptidyl-prolyl cis-trans isomerase activity (PPIase). The present study was designed to analyze the biological activity of recombinant cyclophilin from the marine red algae Pyropia yezoensis (PyCyp). The cyclophilin… read more here.
Keywords: cyclophilin; yezoensis; peptidyl prolyl; recombinant protein ... See more keywords
Peptidyl-prolyl isomerase Pin1 deficiency attenuates angiotensin II-induced abdominal aortic aneurysm formation in ApoE-/- mice.
Sign Up to like & getrecommendations! Published in 2018 at "Journal of molecular and cellular cardiology"
DOI: 10.1016/j.yjmcc.2017.12.006
Abstract: Peptidyl-prolyl isomerase Pin1 has been reported to be associated with endothelial dysfunction. However, the role of smooth muscle Pin1 in the vascular system remains unclear. Here, we examined the potential function of Pin1 in smooth… read more here.
Keywords: isomerase pin1; angiotensin induced; peptidyl prolyl; formation ... See more keywords
Computational and Structure-Based Development of High Potent Cell-Active Covalent Inhibitor Targeting the Peptidyl-Prolyl Isomerase NIMA-Interacting-1 (Pin1).
Sign Up to like & getrecommendations! Published in 2022 at "Journal of medicinal chemistry"
DOI: 10.1021/acs.jmedchem.1c01686
Abstract: The unique proline isomerase peptidyl-prolyl isomerase NIMA-interacting-1 (Pin1) is reported to activate numerous cancer-driving pathways simultaneously, and aberrant Pin1 activation is present in many human cancers. Here, we identified a novel hit compound, ZL-Pin01, that… read more here.
Keywords: isomerase nima; inhibitor; prolyl isomerase; pin1 ... See more keywords
Peptidyl Prolyl Isomerase A Modulates the Liquid–Liquid Phase Separation of Proline-Rich IDPs
Sign Up to like & getrecommendations! Published in 2022 at "Journal of the American Chemical Society"
DOI: 10.1021/jacs.2c07149
Abstract: Liquid–liquid phase separation (LLPS) of intrinsically disordered proteins (IDPs) and the action of molecular chaperones are tightly connected. An important class of molecular chaperones are peptidyl prolyl isomerases, which enhance the cis/trans-isomerization of proline. However,… read more here.
Keywords: liquid phase; peptidyl prolyl; liquid liquid; phase ... See more keywords
Fine-tuning the extent and dynamics of binding cleft opening as a potential general regulatory mechanism in parvulin-type peptidyl prolyl isomerases
Sign Up to like & getrecommendations! Published in 2017 at "Scientific Reports"
DOI: 10.1038/srep44504
Abstract: Parvulins or rotamases form a distinct group within peptidyl prolyl cis-trans isomerases. Their exact mode of action as well as the role of conserved residues in the family are still not unambiguously resolved. Using backbone… read more here.
Keywords: binding cleft; parvulin; extent dynamics; peptidyl prolyl ... See more keywords
FKBP65-dependent peptidyl-prolyl isomerase activity potentiates the lysyl hydroxylase 2-driven collagen cross-link switch
Sign Up to like & getrecommendations! Published in 2017 at "Scientific Reports"
DOI: 10.1038/srep46021
Abstract: Bruck Syndrome is a connective tissue disease associated with inactivating mutations in lysyl hydroxylase 2 (LH2/PLOD2) or FK506 binding protein 65 (FKBP65/FKBP10). However, the functional relationship between LH2 and FKBP65 remains unclear. Here, we postulated… read more here.
Keywords: collagen; peptidyl prolyl; lysyl hydroxylase; collagen cross ... See more keywords
Identification of Salmonella Typhimurium Peptidyl-prolyl cis-trans isomerase B (PPIase B) and assessment of their role in the protein folding.
Sign Up to like & getrecommendations! Published in 2020 at "Protein and peptide letters"
DOI: 10.2174/0929866527666200225124104
Abstract: BACKGROUND Peptidyl-prolyl cis-trans isomerisation (PPIases) enzyme plays a vital role in protein folding. It catalyses the cis-trans isomerisation of peptide bonds, an essential step for newly synthesized protein to acquire its correct functional conformation in… read more here.
Keywords: protein; salmonella typhimurium; cis trans; peptidyl prolyl ... See more keywords
Pinning Down the Transcription: A Role for Peptidyl-Prolyl cis-trans Isomerase Pin1 in Gene Expression
Sign Up to like & getrecommendations! Published in 2020 at "Frontiers in Cell and Developmental Biology"
DOI: 10.3389/fcell.2020.00179
Abstract: Pin1 is a peptidyl-prolyl cis-trans isomerase that specifically binds to a phosphorylated serine or threonine residue preceding a proline (pSer/Thr-Pro) motif and catalyzes the cis-trans isomerization of proline imidic peptide bond, resulting in conformational change… read more here.
Keywords: transcription; prolyl cis; peptidyl prolyl; trans isomerase ... See more keywords
Roles of peptidyl prolyl isomerase Pin1 in viral propagation
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Cell and Developmental Biology"
DOI: 10.3389/fcell.2022.1005325
Abstract: Peptidyl-prolyl isomerase (PPIase) is a unique enzyme that promotes cis-trans isomerization of a proline residue of a target protein. Peptidyl-prolyl cis-trans isomerase NIMA (never in mitosis A)-interacting 1 (Pin1) is a PPIase that binds to… read more here.
Keywords: roles peptidyl; pin1 viral; isomerase pin1; prolyl isomerase ... See more keywords