A Tale of Water Molecules in the Ribosomal Peptidyl Transferase Reaction.
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DOI: 10.1021/acs.biochem.2c00098
Abstract: The peptidyl transferase center (PTC) in the large subunit of the ribosome plays a critical role in protein synthesis by catalyzing the formation of peptide bonds with an astounding speed of about 15 to 20… read more here.
Keywords: water; tale water; water molecules; molecules ribosomal ... See more keywords
Conformation of methylated GGQ in the Peptidyl Transferase Center during Translation Termination
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DOI: 10.1038/s41598-018-20107-8
Abstract: The universally conserved Gly-Gly-Gln (GGQ) tripeptide in release factors or release factor-like surveillance proteins is required to catalyze the release of nascent peptide in the ribosome. The glutamine of the GGQ is methylated post-translationally at… read more here.
Keywords: methylated ggq; transferase center; conformation methylated; peptidyl transferase ... See more keywords
The DEAD-box protein Dbp6 is an ATPase and RNA annealase interacting with the peptidyl transferase center (PTC) of the ribosome
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DOI: 10.1093/nar/gkac1196
Abstract: Abstract Ribosomes are ribozymes, hence correct folding of the rRNAs during ribosome biogenesis is crucial to ensure catalytic activity. RNA helicases, which can modulate RNA–RNA and RNA/protein interactions, are proposed to participate in rRNA tridimensional… read more here.
Keywords: transferase center; rna; dead box; dbp6 atpase ... See more keywords
Rare ribosomal RNA sequences from archaea stabilize the bacterial ribosome
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DOI: 10.1093/nar/gkac1273
Abstract: Ribosomes serve as the universally conserved translators of the genetic code into proteins and must support life across temperatures ranging from below freezing to above the boiling point of water. Ribosomes are capable of functioning… read more here.
Keywords: ribosomal rna; bacterial ribosome; transferase center; peptidyl transferase ... See more keywords