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   Articles with "peptidyl transferase" as a keyword



A Tale of Water Molecules in the Ribosomal Peptidyl Transferase Reaction.

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recommendations! Published in 2022 at "Biochemistry"

DOI: 10.1021/acs.biochem.2c00098

Abstract: The peptidyl transferase center (PTC) in the large subunit of the ribosome plays a critical role in protein synthesis by catalyzing the formation of peptide bonds with an astounding speed of about 15 to 20… read more here.

Keywords: water; tale water; water molecules; molecules ribosomal ... See more keywords

Conformation of methylated GGQ in the Peptidyl Transferase Center during Translation Termination

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recommendations! Published in 2018 at "Scientific Reports"

DOI: 10.1038/s41598-018-20107-8

Abstract: The universally conserved Gly-Gly-Gln (GGQ) tripeptide in release factors or release factor-like surveillance proteins is required to catalyze the release of nascent peptide in the ribosome. The glutamine of the GGQ is methylated post-translationally at… read more here.

Keywords: methylated ggq; transferase center; conformation methylated; peptidyl transferase ... See more keywords

Translational impacts of enzymes that modify ribosomal RNA around the peptidyl transferase centre

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recommendations! Published in 2024 at "RNA Biology"

DOI: 10.1080/15476286.2024.2368305

Abstract: Large ribosomal RNAs (rRNAs) are modified heavily post-transcriptionally in functionally-important regions but, paradoxically, individual knockouts (KOs) of the modification enzymes have minimal impact on Escherichia coli growth. Furthermore, we recently constructed a strain with combined… read more here.

Keywords: peptidyl transferase; impacts enzymes; translational impacts; modification enzymes ... See more keywords

The DEAD-box protein Dbp6 is an ATPase and RNA annealase interacting with the peptidyl transferase center (PTC) of the ribosome

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recommendations! Published in 2023 at "Nucleic Acids Research"

DOI: 10.1093/nar/gkac1196

Abstract: Abstract Ribosomes are ribozymes, hence correct folding of the rRNAs during ribosome biogenesis is crucial to ensure catalytic activity. RNA helicases, which can modulate RNA–RNA and RNA/protein interactions, are proposed to participate in rRNA tridimensional… read more here.

Keywords: transferase center; rna; dead box; dbp6 atpase ... See more keywords

Rare ribosomal RNA sequences from archaea stabilize the bacterial ribosome

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recommendations! Published in 2022 at "Nucleic Acids Research"

DOI: 10.1093/nar/gkac1273

Abstract: Ribosomes serve as the universally conserved translators of the genetic code into proteins and must support life across temperatures ranging from below freezing to above the boiling point of water. Ribosomes are capable of functioning… read more here.

Keywords: ribosomal rna; bacterial ribosome; transferase center; peptidyl transferase ... See more keywords