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   Articles with "peptidyl trna" as a keyword



Vms1/Ankzf1 peptidyl-tRNA hydrolase releases nascent chains from stalled ribosomes

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recommendations! Published in 2018 at "Nature"

DOI: 10.1038/s41586-018-0022-5

Abstract: Ribosomal surveillance pathways scan for ribosomes that are transiently paused or terminally stalled owing to structural elements in mRNAs or nascent chain sequences1, 2. Some stalls in budding yeast are sensed by the GTPase Hbs1,… read more here.

Keywords: nascent chains; trna hydrolase; stalled ribosomes; peptidyl trna ... See more keywords

Structure of Escherichia coli heat shock protein Hsp15 in complex with the ribosomal 50S subunit bearing peptidyl-tRNA

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recommendations! Published in 2022 at "Nucleic Acids Research"

DOI: 10.1093/nar/gkac1035

Abstract: Abstract In Escherichia coli, the heat shock protein 15 (Hsp15) is part of the cellular response to elevated temperature. Hsp15 interacts with peptidyl-tRNA-50S complexes that arise upon dissociation of translating 70S ribosomes, and is proposed… read more here.

Keywords: hsp15; trna; peptidyl trna; heat shock ... See more keywords

Mechanism of release factor-mediated peptidyl-tRNA hydrolysis on the ribosome.

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recommendations! Published in 2025 at "Science"

DOI: 10.1126/science.ads9030

Abstract: Translation termination is essential in all living organisms because it ensures that proteins have lengths strictly defined by their genes. This universal process is mediated by peptide release factors (RFs) that recognize stop codons and… read more here.

Keywords: release; mechanism release; ribosome; peptidyl trna ... See more keywords

Unveiling the Druggable Landscape of Bacterial Peptidyl tRNA Hydrolase: Insights into Structure, Function, and Therapeutic Potential

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recommendations! Published in 2024 at "Biomolecules"

DOI: 10.3390/biom14060668

Abstract: Bacterial peptidyl tRNA hydrolase (Pth) or Pth1 emerges as a pivotal enzyme involved in the maintenance of cellular homeostasis by catalyzing the release of peptidyl moieties from peptidyl-tRNA molecules and the maintenance of a free… read more here.

Keywords: trna hydrolase; peptidyl trna; bacterial peptidyl; pth ... See more keywords