Gingival crevicular fluid semaphorin 4D and peptidylarginine deiminase two levels in periodontal health and disease.
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DOI: 10.1002/jper.18-0608
Abstract: BACKGROUND The aim of this study was to compare the levels of semaphorin 4D (SEMA4D), peptidylarginine deiminase 2 (PAD2) and matrix metalloproteinase-8 (MMP-8) in gingival crevicular fluid (GCF) in patients with periodontal disease and patients… read more here.
Keywords: mmp; total amounts; peptidylarginine deiminase; sema4d pad2 ... See more keywords
Probing the Roles of Calcium-Binding Sites during the Folding of Human Peptidylarginine Deiminase 4
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DOI: 10.1038/s41598-017-02677-1
Abstract: Our recent studies of peptidylarginine deiminase 4 (PAD4) demonstrate that its non-catalytic Ca2+-binding sites play a crucial role in the assembly of the correct geometry of the enzyme. Here, we examined the folding mechanism of… read more here.
Keywords: pad4; site; binding sites; peptidylarginine deiminase ... See more keywords
Peptidylarginine deiminase-4 gene polymorphisms are associated with systemic lupus erythematosus and lupus nephritis
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DOI: 10.1080/03009742.2018.1488273
Abstract: Objective: Peptidylarginine deiminase-4 (PAD4) is highly expressed by neutrophils and essential for citrullination occurring during the formation of neutrophil extracellular traps, which have been implicated in the pathogenesis of systemic lupus erythematosus (SLE) and lupus… read more here.
Keywords: padi4; systemic lupus; lupus erythematosus; lupus nephritis ... See more keywords
Peptidylarginine deiminase enzymes and citrullinated proteins in female reproductive physiology and associated diseases
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DOI: 10.1093/biolre/ioac173
Abstract: Abstract Citrullination, the post-translational modification of arginine residues, is catalyzed by the four catalytically active peptidylarginine deiminase (PAD or PADI) isozymes and alters charge to affect target protein structure and function. PADs were initially characterized… read more here.
Keywords: citrullinated proteins; female reproductive; associated diseases; physiology ... See more keywords
07.14 Novel polymorphism of peptidylarginine deiminase from p. gingivalis augments bacterial pathogenicity and severity of periodontitis
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DOI: 10.1136/annrheumdis-2016-211054.14
Abstract: Background Periodontitis (PD) is the most common chronic inflammatory disease caused by bacterial infection resulting in alveolar bone resorption and tooth loss.1,2 A main causative agent of PD is Porphyromonas gingivalis (Pg). 3,4 This periodontopathogen… read more here.
Keywords: ppad; peptidylarginine deiminase; arthritis; polymorphism ... See more keywords
Relative efficiencies of peptidylarginine deiminase 2 and 4 in generating target sites for anti-citrullinated protein antibodies in fibrinogen, alpha-enolase and histone H3
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DOI: 10.1371/journal.pone.0203214
Abstract: Objective Peptidylarginine deiminase 2 (PAD2) and PAD4 are expressed in the synovium of rheumatoid arthritis (RA) patients and catalyze citrullination of arginine residues in proteins targeted by anti-citrullinated protein antibodies (ACPAs). Little is known about… read more here.
Keywords: pad4; pad2 pad4; target; peptidylarginine deiminase ... See more keywords
In vivo expression of peptidylarginine deiminase in Drosophila melanogaster
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DOI: 10.1371/journal.pone.0227822
Abstract: Peptidylarginine deiminase (PAD) modifies peptidylarginine and converts it to peptidylcitrulline in the presence of elevated calcium. Protein modification can lead to severe changes in protein structure and function, and aberrant PAD activity is linked to… read more here.
Keywords: peptidylarginine deiminase; drosophila melanogaster; expression; pad ... See more keywords
Peptidylarginine Deiminase 2 Autoantibodies Are Linked to Less Severe Disease in Multiple Sclerosis and Post-treatment Lyme Disease
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DOI: 10.3389/fneur.2022.874211
Abstract: Background Peptidylarginine deiminase 2 (PAD2) mediates the post-translational conversion of arginine residues in proteins to citrullines and is highly expressed in the central nervous system (CNS). Dysregulated PAD2 activity has been implicated in the pathogenesis… read more here.
Keywords: anti pad2; disease; expression; peptidylarginine deiminase ... See more keywords