Stereochemistry of polypeptoid chain configurations.
Sign Up to like & getrecommendations! Published in 2019 at "Biopolymers"
DOI: 10.1002/bip.23266
Abstract: Like polypeptides, peptoids, or N-substituted glycine oligomers, have intrinsic conformational preferences due to their amide backbones and close spacing of side chain substituents. However, the conformations that peptoids adopt are distinct from polypeptides due to… read more here.
Keywords: chain; polypeptoid chain; stereochemistry polypeptoid; peptoid ... See more keywords
Helical side chain chemistry of a peptoid-based SP-C analogue: Balancing structural rigidity and biomimicry.
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DOI: 10.1002/bip.23277
Abstract: Surfactant protein C (SP-C) is an important constituent of lung surfactant (LS) and, along with SP-B, is included in exogenous surfactant replacement therapies for treating respiratory distress syndrome (RDS). SP-C's biophysical activity depends upon the… read more here.
Keywords: side chain; chemistry; chain chemistry; peptoid ... See more keywords
Peptoid‐Peptide Hybrid Analogs of the Enterococcus faecalis Fsr Auto‐Inducing Peptide (AIP) Reveal Crucial Structure‐Activity Relationships
Sign Up to like & getrecommendations! Published in 2022 at "ChemBioChem"
DOI: 10.1002/cbic.202200527
Abstract: As multidrug‐resistant bacteria become a more pressing risk to human health, alternate approaches to treating bacterial infections are being increasingly investigated. Enterococcus faecalis is an opportunistic pathogen responsible for a large percentage of secondary enterococci… read more here.
Keywords: peptide hybrid; faecalis fsr; hybrid analogs; enterococcus faecalis ... See more keywords
Amphiphilic Peptoid-Directed Assembly of Oligoanilines into Highly Crystalline Conducting Nanotubes.
Sign Up to like & getrecommendations! Published in 2022 at "Macromolecular rapid communications"
DOI: 10.1002/marc.202100639
Abstract: It is reported herein the synthesis of a novel amphiphilic diblock peptoid bearing a terminal conjugated oligoaniline and its self-assembly into small-diameter (D ≈ 35 nm) crystalline nanotubes with high aspect ratios (>30). It is shown… read more here.
Keywords: assembly oligoanilines; peptoid directed; highly crystalline; directed assembly ... See more keywords
Characterization of PGua4, a Guanidinium-Rich Peptoid that Delivers IgGs to the Cytosol via Macropinocytosis.
Sign Up to like & getrecommendations! Published in 2023 at "Molecular pharmaceutics"
DOI: 10.1021/acs.molpharmaceut.2c00783
Abstract: To investigate the structure-cellular penetration relationship of guanidinium-rich transporters (GRTs), we previously designed PGua4, a five-amino acid peptoid containing a conformationally restricted pattern of eight guanidines, which showed high cell-penetrating abilities and low cell toxicity.… read more here.
Keywords: characterization pgua4; peptoid; macropinocytosis; guanidinium rich ... See more keywords
Genesis of Neuroprotective Peptoid from Aβ30-34 Inhibits Aβ Aggregation and AChE Activity.
Sign Up to like & getrecommendations! Published in 2018 at "ACS chemical neuroscience"
DOI: 10.1021/acschemneuro.8b00071
Abstract: Aβ peptide and hyper-phosphorylated microtubule associated protein (Tau) aggregation causes severe damage to both the neuron membrane and key signal processing microfilament (microtubule) in Alzheimer's disease (AD) brains. To date, the key challenge is to… read more here.
Keywords: ache; inhibits aggregation; neuroprotective peptoid; peptoid ... See more keywords
Abstract 3441: A multivalent peptoid conjugate that inhibits therapy-resistant prostate cancer cell proliferation by modulating androgen receptor transcriptional activity
Sign Up to like & getrecommendations! Published in 2023 at "Cancer Research"
DOI: 10.1158/1538-7445.am2023-3441
Abstract: Prostate cancers adapt to androgen receptor (AR) pathway inhibitors and progress to castration resistance despite the continued expression and function of the AR. We developed a new approach to antagonize the proliferative activity of AR… read more here.
Keywords: prostate cancer; androgen receptor; resistant prostate; peptoid ... See more keywords
Enhanced detection of prion infectivity from blood by preanalytical enrichment with peptoid-conjugated beads
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DOI: 10.1371/journal.pone.0216013
Abstract: Prions cause transmissible infectious diseases in humans and animals and have been found to be transmissible by blood transfusion even in the presymptomatic stage. However, the concentration of prions in body fluids such as blood… read more here.
Keywords: enrichment; prion; peptoid; blood ... See more keywords