Use of Machine Learning to Estimate the Per-Protocol Effect of Low-Dose Aspirin on Pregnancy Outcomes
Sign Up to like & getrecommendations! Published in 2022 at "JAMA Network Open"
DOI: 10.1001/jamanetworkopen.2021.43414
Abstract: Key Points Question How can machine learning be used to estimate per-protocol effects in randomized clinical trials? Findings In a cohort of 1227 women derived from secondary analysis of a randomized clinical trial, ensemble machine… read more here.
Keywords: per protocol; protocol; estimate per; machine learning ... See more keywords
Electronic medical records can be used to emulate target trials of sustained treatment strategies.
Sign Up to like & getrecommendations! Published in 2018 at "Journal of clinical epidemiology"
DOI: 10.1016/j.jclinepi.2017.11.021
Abstract: OBJECTIVE To emulate three target trials: single treatment vs. no treatment, joint treatment vs. no treatment, and head-to-head comparison of two treatments, we explain how to estimate the observational analogs of intention-to-treat and per-protocol effects,… read more here.
Keywords: per protocol; treatment; target trials; electronic medical ... See more keywords
A Per-Protocol Analysis using Inverse Probability of Censoring Weights in a Randomized Trial of Initial PI versus NNRTI Regimens in Children.
Sign Up to like & getrecommendations! Published in 2023 at "American journal of epidemiology"
DOI: 10.1093/aje/kwad054
Abstract: Protocol adherence may influence measured treatment effectiveness in randomized controlled trials. Using data from a multicenter trial from Europe and North and South America in 2002-2009 of children with HIV-1 randomized to initial protease inhibitor… read more here.
Keywords: per protocol; probability censoring; nnrti regimens; inverse probability ... See more keywords
Intent-to-Treat (ITT) vs Completer or Per-Protocol Analysis in Randomized Controlled Trials
Sign Up to like & getrecommendations! Published in 2022 at "Indian Journal of Psychological Medicine"
DOI: 10.1177/02537176221101996
Abstract: In randomized controlled trials, randomization creates groups that are reasonably well balanced on all baseline variables, whether measured, unmeasured, or unknown. Postbaseline events disturb this balance, resulting in postrandomization biases. Drop-out is one such event.… read more here.
Keywords: per protocol; completer; randomized controlled; controlled trials ... See more keywords
Randomized Trial for Weight Loss Using a Digital Therapeutic Application.
Sign Up to like & getrecommendations! Published in 2021 at "Journal of diabetes science and technology"
DOI: 10.1177/19322968211000815
Abstract: BACKGROUND Smartphones present a near-ubiquitous channel through which structured lifestyle change can reduce risk or progression of the most common noncommunicable diseases. We explored whether a digital structured lifestyle program enhances weight loss. METHODS We… read more here.
Keywords: intervention; weight loss; group; digital therapeutic ... See more keywords