CRISPR/Cas‐mediated Fubp1 silencing disrupts circadian oscillation of Per1 protein via downregulating Syncrip expression
Sign Up to like & getrecommendations! Published in 2019 at "Cell Biology International"
DOI: 10.1002/cbin.11242
Abstract: Most living organisms have physiological and behavioral circadian rhythms controlled by molecular clocks. In mammals, several core clock genes show self‐perpetuating oscillation profiles of their messenger RNAs (mRNAs) and proteins through an auto‐regulatory transcription–translation feedback… read more here.
Keywords: per1 protein; cas mediated; crispr cas; oscillation ... See more keywords
The Circadian Clock Protein PER1 is Important in Maintaining Endothelin Axis Regulation in Dahl Salt Sensitive Rats.
Sign Up to like & getrecommendations! Published in 2022 at "Canadian journal of physiology and pharmacology"
DOI: 10.1139/cjpp-2022-0134
Abstract: Endothelin-1 (ET-1) is a peptide hormone that acts on its receptors to regulate sodium handling in the kidney's collecting duct. Dysregulation of the endothelin axis is associated with various diseases, including salt-sensitive hypertension and chronic… read more here.
Keywords: circadian clock; per1; regulation; endothelin axis ... See more keywords
Abstract A027: Defining the role of PER1 and circadian rhythm dysregulation in KRAS/LKB1-mutant lung adenocarcinoma
Sign Up to like & getrecommendations! Published in 2023 at "Molecular Cancer Research"
DOI: 10.1158/1557-3125.ras23-a027
Abstract: KRAS and LKB1 are frequently co-mutated in lung adenocarcinoma and characterize a particularly aggressive, metastatic, and treatment-resistant subtype of this disease. We recently published that the outputs of biological rhythm pathways downstream of the AMPK… read more here.
Keywords: lkb1 mutant; kras lkb1; per1; lung adenocarcinoma ... See more keywords
Knockout of the Circadian Clock Protein PER1 (Period1) Exacerbates Hypertension and Increases Kidney Injury in Dahl Salt-Sensitive Rats
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DOI: 10.1161/hypertensionaha.122.19316
Abstract: Background: Circadian rhythms play an essential role in physiological function. The molecular clock that underlies circadian physiological function consists of a core group of transcription factors, including the protein PER1 (Period1). Studies in mice show… read more here.
Keywords: hypertension; pressure; per1; ssper1 rats ... See more keywords
PER1 Is a Prognostic Biomarker and Correlated With Immune Infiltrates in Ovarian Cancer
Sign Up to like & getrecommendations! Published in 2021 at "Frontiers in Genetics"
DOI: 10.3389/fgene.2021.697471
Abstract: Background: Period circadian protein homolog 1 (PER1) is an important component of the biorhythm molecular oscillation system and plays an important part in the development and progression of mammalian cancer. However, the correlations of PER1… read more here.
Keywords: per1 expression; per1; expression; ovarian cancer ... See more keywords