Disrupting Circadian Rhythm via the PER1–HK2 Axis Reverses Trastuzumab Resistance in Gastric Cancer
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DOI: 10.1158/0008-5472.can-21-1820
Abstract: In trastuzumab-resistant HER2-positive gastric cancer, glycolysis fluctuates with a circadian oscillation regulated by the BMAL1–CLOCK–PER1–HK2 axis, which can be disrupted with a metformin-based chronotherapy to overcome trastuzumab resistance. read more here.
Keywords: hk2 axis; per1 hk2; gastric cancer; trastuzumab resistance ... See more keywords