Sirt6 deacetylase activity regulates circadian rhythms via Per2.
Sign Up to like & getrecommendations! Published in 2019 at "Biochemical and biophysical research communications"
DOI: 10.1016/j.bbrc.2019.01.143
Abstract: Circadian clock relies on a transcription and translation feedback loop (TTFL). Two transcription factors, i.e. Bmal1 and Clock, activate the transcription of Period (Per) and Cryptochrome (Cry), which inhibit their own transcription when accumulated to… read more here.
Keywords: per2; circadian rhythms; sirt6 deacetylase; rhythms ... See more keywords
Intense Light-Mediated Circadian Cardioprotection via Transcriptional Reprogramming of the Endothelium
Sign Up to like & getrecommendations! Published in 2019 at "Cell reports"
DOI: 10.1016/j.celrep.2019.07.020
Abstract: SUMMARY Consistent daylight oscillations and abundant oxygen availability are fundamental to human health. Here, we investigate the intersection between light-sensing (Period 2 [PER2]) and oxygen-sensing (hypoxia-inducible factor [HIF1A]) pathways in cellular adaptation to myocardial ischemia.… read more here.
Keywords: mediated circadian; per2; light mediated; myocardial ischemia ... See more keywords
Cryptochrome proteins regulate the circadian intracellular behavior and localization of PER2 in mouse suprachiasmatic nucleus neurons
Sign Up to like & getrecommendations! Published in 2022 at "Proceedings of the National Academy of Sciences of the United States of America"
DOI: 10.1073/pnas.2113845119
Abstract: Significance The suprachiasmatic nucleus (SCN), the master circadian clock of the mammalian brain, coordinates cellular clocks across the organism to regulate daily rhythms of physiology and behavior. SCN timekeeping pivots around transcriptional/translational feedback loops whereby… read more here.
Keywords: localization; cry; scn; cry1 ... See more keywords
Per1 mutation enhances masking responses in mice
Sign Up to like & getrecommendations! Published in 2022 at "Chronobiology International"
DOI: 10.1080/07420528.2022.2126321
Abstract: ABSTRACT Light can restrict the activity of an animal to a diurnal or nocturnal niche by synchronizing its endogenous clock (entrainment) which controls the sleep wake cycle. Light can also directly change an animal’s activity… read more here.
Keywords: masking responses; responses mice; per1 mutation; per1 per2 ... See more keywords
The circadian gene, Per2, influences methamphetamine sensitization and reward through the dopaminergic system in the striatum of mice
Sign Up to like & getrecommendations! Published in 2018 at "Addiction Biology"
DOI: 10.1111/adb.12663
Abstract: Drug addiction is a chronic and relapsing brain disorder, influenced by complex interactions between endogenous and exogenous factors. Per2, a circadian gene, plays a role in drug addiction. Previous studies using Per2‐knockout mice have shown… read more here.
Keywords: addiction; per2; circadian gene; mice ... See more keywords
Depression‐like behavior is associated with lower Per2 mRNA expression in the lateral habenula of rats
Sign Up to like & getrecommendations! Published in 2020 at "Genes"
DOI: 10.1111/gbb.12702
Abstract: Circadian rhythm dysfunction is primary symptom of depression and is closely related to depression onset. The role of the lateral habenula (LHb) of the thalamus in the pathogenesis of depression has been a research topic… read more here.
Keywords: depression; per2; lateral habenula; like behavior ... See more keywords
Impacts of Circadian Gene Period2 Knockout on Intestinal Metabolism and Hepatic Antioxidant and Inflammation State in Mice
Sign Up to like & getrecommendations! Published in 2022 at "Oxidative Medicine and Cellular Longevity"
DOI: 10.1155/2022/7896371
Abstract: The period circadian regulator 2 (Per2) gene is important for the modulations of rhythmic homeostasis in the gut and liver; disruption will cause metabolic diseases, such as obesity, diabetes, and fatty liver. Herein, we investigated… read more here.
Keywords: inflammation; metabolism; intestinal metabolism; antioxidant inflammation ... See more keywords
Knockout of the circadian gene, Per2, disrupts corticosterone secretion and results in depressive‐like behaviors and deficits in startle responses
Sign Up to like & getrecommendations! Published in 2021 at "BMC Neuroscience"
DOI: 10.1186/s12868-020-00607-y
Abstract: Background The Period Circadian Regulator 2 ( Per2 ) gene is important for the modulation of circadian rhythms that influence biological processes. Circadian control of the hypothalamus-pituitary-adrenal (HPA) axis is critical for regulation of hormones… read more here.
Keywords: per2; hpa axis; like behaviors; depressive like ... See more keywords
Complementary phase responses via functional differentiation of dual negative feedback loops
Sign Up to like & getrecommendations! Published in 2021 at "PLoS Computational Biology"
DOI: 10.1371/journal.pcbi.1008774
Abstract: Multiple feedback loops are often found in gene regulations for various cellular functions. In mammalian circadian clocks, oscillations of Period1 (Per1) and Period2 (Per2) expression are caused by interacting negative feedback loops (NFLs) whose protein… read more here.
Keywords: phase; per2; phase responses; feedback loops ... See more keywords
Targeted modification of the Per2 clock gene alters circadian function in mPer2luciferase (mPer2Luc) mice
Sign Up to like & getrecommendations! Published in 2021 at "PLoS Computational Biology"
DOI: 10.1371/journal.pcbi.1008987
Abstract: Modification of the Per2 clock gene in mPer2Luc reporter mice significantly alters circadian function. Behavioral period in constant dark is lengthened, and dissociates into two distinct components in constant light. Rhythms exhibit increased bimodality, enhanced… read more here.
Keywords: clock gene; per2; modification per2; per2 clock ... See more keywords
Intense light as anticoagulant therapy in humans
Sign Up to like & getrecommendations! Published in 2020 at "PLoS ONE"
DOI: 10.1371/journal.pone.0244792
Abstract: Blood coagulation is central to myocardial ischemia and reperfusion (IR) injury. Studies on the light elicited circadian rhythm protein Period 2 (PER2) using whole body Per2-/- mice found deficient platelet function and reduced clotting which… read more here.
Keywords: per2; intense light; mice; therapy ... See more keywords