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   Articles with "per3" as a keyword



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The impact of Mendelian sleep and circadian genetic variants in a population setting

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recommendations! Published in 2022 at "PLoS Genetics"

DOI: 10.1371/journal.pgen.1010356

Abstract: Rare variants in ten genes have been reported to cause Mendelian sleep conditions characterised by extreme sleep duration or timing. These include familial natural short sleep (ADRB1, DEC2/BHLHE41, GRM1 and NPSR1), advanced sleep phase (PER2,… read more here.

Keywords: previously reported; per3; mendelian sleep; sleep circadian ... See more keywords
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Dysregulated expression of suppressor loop of circadian rhythm genes in colorectal cancer pathogenesis.

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recommendations! Published in 2022 at "Minerva medica"

DOI: 10.23736/s0026-4806.22.07981-2

Abstract: BACKGROUND Colorectal cancer (CRC) is a heterogeneous disease and activation of WNT and TGFβ mediated oncogenic pathways is frequently observed in this pathology. However, to date, limited reports have been published addressing the association of… read more here.

Keywords: per3; expression; suppressor loop; crc ... See more keywords
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PERIOD3 (PER3) VNTR Variant Associated with Seasonal Pattern and Family History in Bipolar Disorder.

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recommendations! Published in 2022 at "Psychiatria Danubina"

DOI: 10.24869/psyd.2022.695

Abstract: BACKGROUND Dysregulation of circadian rhythms has been thought to be associated with psychiatric disorders such as bipolar disorder (BD) and depression. We aimed to evaluate the relationship between clinical specifiers of BD, mainly seasonal pattern… read more here.

Keywords: vntr variant; bipolar disorder; per3; family history ... See more keywords
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Relationship between APOE, PER2, PER3 and OX2R Genetic Variants and Neuropsychiatric Symptoms in Patients with Alzheimer’s Disease

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recommendations! Published in 2023 at "International Journal of Environmental Research and Public Health"

DOI: 10.3390/ijerph20054412

Abstract: Alzheimer’s disease (AD) is characterized by the presence of neuropsychiatric or behavioral and psychological symptoms of dementia (BPSD). BPSD have been associated with the APOE_ε4 allele, which is also the major genetic AD risk factor.… read more here.

Keywords: genetic variants; alzheimer disease; per3; gene ... See more keywords

Overexpression of PER3 Inhibits Self-Renewal Capability and Chemoresistance of Colorectal Cancer Stem-Like Cells via Inhibition of Notch and β-Catenin Signaling

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recommendations! Published in 2017 at "Oncology Research"

DOI: 10.3727/096504016x14772331883976

Abstract: PER3, a circadian clock gene, plays an important role in colorectal cancer, but its action and underlying mechanism in colorectal cancer stem-like cells (CSCs) remain unclear. In this study, the colorectal CSCs were enriched in… read more here.

Keywords: colorectal cscs; overexpression per3; self renewal; per3 ... See more keywords