Intravenous Perampanel as an Interchangeable Alternative to Oral Perampanel: A Randomized, Crossover, Phase I Pharmacokinetic and Safety Study
Sign Up to like & getrecommendations! Published in 2022 at "Clinical Pharmacology in Drug Development"
DOI: 10.1002/cpdd.1107
Abstract: Intravenous (IV) drug administration enables treatment of epilepsy when oral administration is temporarily not feasible. Perampanel is a once‐daily antiseizure medication currently available as oral formulations. Study 050 (NCT03376997) was an open‐label, randomized, single‐dose, crossover… read more here.
Keywords: safety; oral perampanel; alternative oral; perampanel ... See more keywords
Therapeutic drug monitoring of perampanel in children diagnosed with epilepsy: Focus on influencing factors on the plasma concentration‐to‐dose ratio
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DOI: 10.1002/epi4.12653
Abstract: This study aimed to investigate the efficacy and tolerability of perampanel (PER) therapy and to optimize a specific plasma reference range for PER in children. Another major aim was to evaluate the potential determinators of… read more here.
Keywords: monitoring perampanel; therapeutic drug; concentration; perampanel children ... See more keywords
Efficacy and safety of perampanel in refractory and super-refractory status epilepticus: cohort study of 81 patients and literature review
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DOI: 10.1007/s00415-021-10506-9
Abstract: The effective dose of perampanel in status epilepticus (SE), refractory SE (RSE), and super-refractory SE (SRSE) in humans is unknown, and the potential of perampanel in treating SE has not been evaluated in a large… read more here.
Keywords: status epilepticus; refractory; perampanel; super refractory ... See more keywords
Intrathecally administered perampanel alleviates neuropathic and inflammatory pain in rats.
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DOI: 10.1016/j.ejphar.2020.172949
Abstract: Chronic pain conditions such as neuropathic pain and persistent inflammatory pain are difficult to manage. Alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptors modulate nociceptive processing at the spinal dorsal horn. Previous studies have shown that intrathecal AMPA receptor… read more here.
Keywords: neuropathic inflammatory; inflammatory pain; pain; ampa receptor ... See more keywords
The anxiolytic effect of perampanel and possible mechanisms mediating its anxiolytic effect in mice.
Sign Up to like & getrecommendations! Published in 2020 at "Life sciences"
DOI: 10.1016/j.lfs.2020.118359
Abstract: AIMS The aim of this study is to investigate the anxiolytic activity of perampanel, a non-competitive antagonist of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid (AMPA)-type glutamate receptors, which is approved for partial-onset seizures in patients with epilepsy, and… read more here.
Keywords: effect perampanel; effect; perampanel; anxiolytic activity ... See more keywords
A Liquid Chromatography-Mass Spectrometry Assay for Determination of Perampanel and Concomitant Antiepileptic Drugs in the Plasma of Patients With Epilepsy Compared With a Fluorescent HPLC Assay
Sign Up to like & getrecommendations! Published in 2018 at "Therapeutic Drug Monitoring"
DOI: 10.1097/ftd.0000000000000531
Abstract: Background: Perampanel is a novel noncompetitive selective antagonist at the postsynaptic ionotropic alpha-amino-3-hydroxy-5-methyl-4-isoxazoleproprionic acid (AMPA) glutamate receptor, which is approved as an adjunctive agent for the treatment of partial-onset seizure with or without secondary generalization… read more here.
Keywords: mass spectrometry; chromatography mass; liquid chromatography; patients epilepsy ... See more keywords
Effectiveness and safety of perampanel in adults with mesial temporal epilepsy
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DOI: 10.1097/md.0000000000017171
Abstract: Abstract Mesial temporal lobe epilepsy (MTLE) is a common epilepsy syndrome often refractory to antiepileptic drug (AED) treatment. The purpose of this study was to evaluate the effectiveness and tolerability of perampanel (PER) as add-on… read more here.
Keywords: mesial temporal; treatment; epilepsy; seizure ... See more keywords
Effectiveness and tolerability of adjunctive perampanel in pediatric patients (aged 4–12 years) with refractory epilepsy: An observational study
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DOI: 10.1097/md.0000000000031408
Abstract: Information on the effects of perampanel in Chinese children ≤12 years of age with refractory epilepsy is limited; thus, we conducted an observational study to assess the effectiveness, safety, and tolerability of adjunctive perampanel in… read more here.
Keywords: patients aged; refractory epilepsy; aged years; perampanel ... See more keywords
Pharmacokinetic/pharmacodynamic analysis of adjunctive perampanel in subjects with partial‐onset seizures
Sign Up to like & getrecommendations! Published in 2018 at "Acta Neurologica Scandinavica"
DOI: 10.1111/ane.12874
Abstract: Explore perampanel pharmacokinetics (PK) in all subjects (aged ≥12 years) vs adolescents (aged ≥12 to ≤17 years) with partial‐onset seizures (POS) and identify factors explaining between‐subject variability in efficacy using a population PK/pharmacodynamic (PD) analysis. read more here.
Keywords: partial onset; perampanel; pharmacodynamic analysis; onset seizures ... See more keywords
AMPA receptor antagonist perampanel affects glioblastoma cell growth and glutamate release in vitro
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DOI: 10.1371/journal.pone.0211644
Abstract: Epileptic seizures are frequent in patients with glioblastoma, and anticonvulsive treatment is often necessary. While clinical guidelines recommend all approved anticonvulsants, so far it is still unclear which of the available drugs is the best… read more here.
Keywords: glutamate release; cell lines; cell; glioblastoma cell ... See more keywords
Perampanel Reduces Brain Damage via Induction of M2 Microglia in a Neonatal Rat Stroke Model
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DOI: 10.2147/ijn.s361377
Abstract: Purpose Ischemic stroke is a leading cause of death and disability worldwide. Additionally, neonatal ischemia is a common cause of neonatal brain injury, resulting in cerebral palsy with subsequent learning disabilities and epilepsy. However, there… read more here.
Keywords: brain; plga; perampanel; per loaded ... See more keywords