Comparison of In Vitro and In Vivo Percutaneous Absorption Across Human Skin Using BAY1003803 Formulated as Ointment and Cream
Sign Up to like & getrecommendations! Published in 2019 at "Clinical Pharmacology in Drug Development"
DOI: 10.1002/cpdd.736
Abstract: Direct comparisons between skin absorption data and clinical pharmacokinetic data are rare. Here we use the lipophilic nonsteroidal selective glucocorticoid receptor agonist BAY1003803 to make such a comparison. The objective is to find the extent… read more here.
Keywords: absorption; percutaneous absorption; human skin; bay1003803 ... See more keywords
Effects of skin region and relative lipophilicity on percutaneous absorption in the toad Rhinella marina.
Sign Up to like & getrecommendations! Published in 2019 at "Environmental toxicology and chemistry"
DOI: 10.1002/etc.4302
Abstract: Owing to the dynamic interaction between frog skin and the environment, xenobiotics in frog habitats are of particular concern, and knowledge of percutaneous absorption in frog skin is necessary for risk-mitigation purposes. Baseline transdermal kinetics… read more here.
Keywords: absorption; percutaneous absorption; rhinella marina; skin region ... See more keywords
Percutaneous absorption and brain distribution facilitation of borneol on tetramethylpyrazine in a microemulsion-based transdermal therapeutic system
Sign Up to like & getrecommendations! Published in 2019 at "Asian Journal of Pharmaceutical Sciences"
DOI: 10.1016/j.ajps.2018.06.003
Abstract: In this study, we show that the percutaneous absorption and brain distribution of tetramethylpyrazine (TMP) is enhanced when combined with borneol (BN) in a microemulsion-based transdermal therapeutic system (ME-TTS). The formulation of the TMP and… read more here.
Keywords: percutaneous absorption; microemulsion; tmp; brain ... See more keywords
Percutaneous Absorption of Polycyclic Aromatic Compounds from Fume Condensates of Paving and Built Up Roofing Asphalts
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DOI: 10.1080/10406638.2018.1509362
Abstract: Abstract Paving and roofing workers can be exposed to low levels of polycyclic aromatic compounds (PACs) while working with asphalt at elevated temperatures via both the inhalation and dermal routes. Inhalation exposure date are readily… read more here.
Keywords: percutaneous absorption; aromatic compounds; built roofing; polycyclic aromatic ... See more keywords
Identification of the Constituents of Percutaneous Absorption from Duhaldea nervosa Based on UHPLC-Q-Exactive Orbitrap MS and Microdialysis Technique
Sign Up to like & getrecommendations! Published in 2019 at "International Journal of Analytical Chemistry"
DOI: 10.1155/2019/8328942
Abstract: Duhaldea nervosa (D. nervosa) has been used for treatment of bone fracture by external use. Thus, the percutaneous absorption was crucial to the effect of D. nervosa, especially the constituents of percutaneous absorption. However, the… read more here.
Keywords: absorption; percutaneous absorption; constituents percutaneous; identification constituents ... See more keywords
Evaluation of an Anhydrous Permeation-Enhancing Vehicle for Percutaneous Absorption of Hormones
Sign Up to like & getrecommendations! Published in 2022 at "AAPS PharmSciTech"
DOI: 10.1208/s12249-022-02352-3
Abstract: The efficiency and safety of hormone delivery through the skin partly depend on the appropriate choice of vehicle and the type of formulation. The present study reports the skin cytotoxicity, irritancy, and safety of a… read more here.
Keywords: percutaneous absorption; permeation enhancing; absorption hormones; vehicle ... See more keywords
Transdermal Oxandrolone: Ex Vivo Percutaneous Absorption Study.
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DOI: 10.2174/1567201813666160502142032
Abstract: BACKGROUND Oxandrolone is a potent synthetic testosterone analogue that possesses strong anabolic property and weak androgenic activity. Apart of their clinical implicances, oral oxandrolone can potentially promote several adverse effects. It is known that the… read more here.
Keywords: percutaneous absorption; study; drug; transdermal oxandrolone ... See more keywords
A Mathematical Approach Using Strat-M® to Predict the Percutaneous Absorption of Chemicals under Finite Dose Conditions
Sign Up to like & getrecommendations! Published in 2022 at "Pharmaceutics"
DOI: 10.3390/pharmaceutics14071370
Abstract: Estimation of the percutaneous absorption is essential for the safety assessment of cosmetic and dermopharmaceutical products. Currently, an artificial membrane, Strat-M®, has been focused on as the tool which could obtain the permeation parameters close… read more here.
Keywords: using strat; percutaneous absorption; finite dose; permeation parameters ... See more keywords