Enantioselective organocatalytic amination of 2-perfluoroalkyl-oxazol-5(2H)-ones towards the synthesis of chiral N,O-aminals with perfluoroalkyl and amino groups
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DOI: 10.1039/d1qo00569c
Abstract: Herein, the first highly enantioselective amination at the C-2 position of 2-perfluoroalkyl-oxazol-5(2H)-ones to phenylazocarboxylates using a (1R,2R)-cyclohexane-1,2-diamine-derived urea–tertiary amine as a bifunctional catalyst is presented. Two efficient asymmetric transformation processes were achieved through the formation… read more here.
Keywords: perfluoroalkyl oxazol; amination; perfluoroalkyl; oxazol ones ... See more keywords