Na2S·9H2O Enabled Defluorodisulfuration and Hydrodefluorination of Perfluorobutyl Tetralones: Synthesis of Trifluoromethyl 1,2-Dithioles.
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DOI: 10.1021/acs.orglett.3c01573
Abstract: An unprecedented defluorocyclization of perfluorobutyl tetralones with Na2S·9H2O was developed for the synthesis of trifluoromethyl 1,2-dithioles, which provided chemists novel access to biologically and pharmaceutically relevant organofluorides. Successive C(sp3)-F bond functionalization at the perfluoroalkyl chain… read more here.
Keywords: na2s 9h2o; synthesis trifluoromethyl; trifluoromethyl dithioles; perfluorobutyl tetralones ... See more keywords