Impact of Portable Normothermic Blood-Based Machine Perfusion on Outcomes of Liver Transplant
Sign Up to like & getrecommendations! Published in 2022 at "JAMA Surgery"
DOI: 10.1001/jamasurg.2021.6781
Abstract: Key Points Question Can oxygenated portable normothermic perfusion of deceased donor livers for transplant improve outcomes compared with the current standard of care using ischemic cold storage? Findings In this multicenter randomized clinical trial of… read more here.
Keywords: portable normothermic; outcomes liver; liver transplant; machine perfusion ... See more keywords
Multiphoton-Guided Creation of Complex Organ-Specific Microvasculature.
Sign Up to like & getrecommendations! Published in 2021 at "Advanced healthcare materials"
DOI: 10.1002/adhm.202100031
Abstract: Engineering functional human tissues in vitro is currently limited by difficulty replicating the small caliber, complex connectivity, cellularity, and 3D curvature of the native microvasculature. Multiphoton ablation has emerged as a promising technique for fabrication… read more here.
Keywords: creation; organ specific; perfusion; multiphoton ... See more keywords
Democratizing Organ-On-Chip Technologies With a Modular, Reusable, and Perfusion-Ready Microphysiological System.
Sign Up to like & getrecommendations! Published in 2025 at "Advanced healthcare materials"
DOI: 10.1002/adhm.202502202
Abstract: Organ‐on‐chip (OOC) technologies, also called microphysiological systems (MPS), offer dynamic microenvironments that improve upon static culture systems, yet widespread adoption has been hindered by fabrication complexity, reliance on polydimethylsiloxane (PDMS), and limited modularity. Here, a… read more here.
Keywords: system; culture; perfusion; chip ... See more keywords
Microthrombus-Targeting Micelles for Neurovascular Remodeling and Enhanced Microcirculatory Perfusion in Acute Ischemic Stroke.
Sign Up to like & getrecommendations! Published in 2019 at "Advanced materials"
DOI: 10.1002/adma.201808361
Abstract: Reperfusion injury exists as the major obstacle to full recovery of neuron functions after ischemic stroke onset and clinical thrombolytic therapies. Complex cellular cascades including oxidative stress, neuroinflammation, and brain vascular impairment occur within neurovascular… read more here.
Keywords: ischemic stroke; perfusion; targeting micelles; microthrombus targeting ... See more keywords
Antihypertension Nanoblockers Increase Intratumoral Perfusion of Sequential Cytotoxic Nanoparticles to Enhance Chemotherapy Efficacy against Pancreatic Cancer
Sign Up to like & getrecommendations! Published in 2022 at "Advanced Science"
DOI: 10.1002/advs.202201931
Abstract: Pancreatic ductal adenocarcinoma (PDAC), one of the worst prognosis types of tumors, is characterized by dense extracellular matrix, which compresses tumor vessels and forms a physical barrier to inhibit therapeutic drug penetration and efficacy. Herein,… read more here.
Keywords: antihypertension; losartan; pancreatic cancer; perfusion ... See more keywords
Comparison of Perfusion Imaging Definitions of the No‐Reflow Phenomenon after Thrombectomy—What Is the Best Perfusion Imaging Definition?
Sign Up to like & getrecommendations! Published in 2024 at "Annals of Neurology"
DOI: 10.1002/ana.27073
Abstract: The no‐reflow phenomenon is a potential contributor to poor outcome despite successful thrombectomy. There are multiple proposed imaging‐based definitions of no‐reflow leading to wide variations in reported prevalence. We investigated the agreement between existing imaging… read more here.
Keywords: imaging definitions; definitions reflow; reflow phenomenon; perfusion imaging ... See more keywords
Extruded Bioreactor Perfusion Culture Supports the Chondrogenic Differentiation of Human Mesenchymal Stem/Stromal Cells in 3D Porous Poly (ε-Caprolactone) Scaffolds.
Sign Up to like & getrecommendations! Published in 2019 at "Biotechnology journal"
DOI: 10.1002/biot.201900078
Abstract: BACKGROUND Novel bioengineering strategies for the ex vivo fabrication of native-like tissue-engineered cartilage are crucial for the translation of these approaches to clinically manage highly prevalent and debilitating joint diseases. Bioreactors that provide different biophysical… read more here.
Keywords: bioreactor; perfusion culture; chondrogenic differentiation; perfusion ... See more keywords
Mini‐ and macro‐scale direct perfusion bioreactors with optimized flow for engineering 3D tissues
Sign Up to like & getrecommendations! Published in 2022 at "Biotechnology Journal"
DOI: 10.1002/biot.202200405
Abstract: Bioreactors enabling direct perfusion of cell suspensions or culture media through the pores of 3D scaffolds have long been used in tissue engineering to improve cell seeding efficiency as well as uniformity of cell distribution… read more here.
Keywords: macro scale; cell; perfusion; engineering ... See more keywords
Biomass specific perfusion rate as a control lever for the continuous manufacturing of biosimilar monoclonal antibodies from CHO cell cultures
Sign Up to like & getrecommendations! Published in 2024 at "Biotechnology Journal"
DOI: 10.1002/biot.202400092
Abstract: Continuous manufacturing enables high volumetric productivities of biologics such as monoclonal antibodies. However, it is challenging to maintain both high viable cell densities and productivities at the same time for long culture durations. One of… read more here.
Keywords: specific perfusion; perfusion rate; cell; perfusion ... See more keywords
Cell‐controlled hybrid perfusion fed‐batch CHO cell process provides significant productivity improvement over conventional fed‐batch cultures
Sign Up to like & getrecommendations! Published in 2017 at "Biotechnology and Bioengineering"
DOI: 10.1002/bit.26259
Abstract: A simple method originally designed to control lactate accumulation in fed‐batch cultures of Chinese Hamster Ovary (CHO) cells has been modified and extended to allow cells in culture to control their own rate of perfusion… read more here.
Keywords: perfusion; batch cultures; fed batch; batch ... See more keywords
Perfusion applied to a 3D model of bone metastasis results in uniformly dispersed mechanical stimuli
Sign Up to like & getrecommendations! Published in 2018 at "Biotechnology and Bioengineering"
DOI: 10.1002/bit.26524
Abstract: Breast cancer most frequently metastasizes to the skeleton. Bone metastatic cancer is incurable and induces wide‐spread bone osteolysis, resulting in significant patient morbidity and mortality. Mechanical cues in the skeleton are an important microenvironmental parameter… read more here.
Keywords: model bone; perfusion; bone; model ... See more keywords