Impact of Portable Normothermic Blood-Based Machine Perfusion on Outcomes of Liver Transplant
Sign Up to like & getrecommendations! Published in 2022 at "JAMA Surgery"
DOI: 10.1001/jamasurg.2021.6781
Abstract: Key Points Question Can oxygenated portable normothermic perfusion of deceased donor livers for transplant improve outcomes compared with the current standard of care using ischemic cold storage? Findings In this multicenter randomized clinical trial of… read more here.
Keywords: portable normothermic; outcomes liver; liver transplant; machine perfusion ... See more keywords
Multiphoton-Guided Creation of Complex Organ-Specific Microvasculature.
Sign Up to like & getrecommendations! Published in 2021 at "Advanced healthcare materials"
DOI: 10.1002/adhm.202100031
Abstract: Engineering functional human tissues in vitro is currently limited by difficulty replicating the small caliber, complex connectivity, cellularity, and 3D curvature of the native microvasculature. Multiphoton ablation has emerged as a promising technique for fabrication… read more here.
Keywords: creation; organ specific; perfusion; multiphoton ... See more keywords
Microthrombus-Targeting Micelles for Neurovascular Remodeling and Enhanced Microcirculatory Perfusion in Acute Ischemic Stroke.
Sign Up to like & getrecommendations! Published in 2019 at "Advanced materials"
DOI: 10.1002/adma.201808361
Abstract: Reperfusion injury exists as the major obstacle to full recovery of neuron functions after ischemic stroke onset and clinical thrombolytic therapies. Complex cellular cascades including oxidative stress, neuroinflammation, and brain vascular impairment occur within neurovascular… read more here.
Keywords: ischemic stroke; perfusion; targeting micelles; microthrombus targeting ... See more keywords
Antihypertension Nanoblockers Increase Intratumoral Perfusion of Sequential Cytotoxic Nanoparticles to Enhance Chemotherapy Efficacy against Pancreatic Cancer
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DOI: 10.1002/advs.202201931
Abstract: Pancreatic ductal adenocarcinoma (PDAC), one of the worst prognosis types of tumors, is characterized by dense extracellular matrix, which compresses tumor vessels and forms a physical barrier to inhibit therapeutic drug penetration and efficacy. Herein,… read more here.
Keywords: antihypertension; losartan; pancreatic cancer; perfusion ... See more keywords
Extruded Bioreactor Perfusion Culture Supports the Chondrogenic Differentiation of Human Mesenchymal Stem/Stromal Cells in 3D Porous Poly (ε-Caprolactone) Scaffolds.
Sign Up to like & getrecommendations! Published in 2019 at "Biotechnology journal"
DOI: 10.1002/biot.201900078
Abstract: BACKGROUND Novel bioengineering strategies for the ex vivo fabrication of native-like tissue-engineered cartilage are crucial for the translation of these approaches to clinically manage highly prevalent and debilitating joint diseases. Bioreactors that provide different biophysical… read more here.
Keywords: bioreactor; perfusion culture; chondrogenic differentiation; perfusion ... See more keywords
Mini‐ and macro‐scale direct perfusion bioreactors with optimized flow for engineering 3D tissues
Sign Up to like & getrecommendations! Published in 2022 at "Biotechnology Journal"
DOI: 10.1002/biot.202200405
Abstract: Bioreactors enabling direct perfusion of cell suspensions or culture media through the pores of 3D scaffolds have long been used in tissue engineering to improve cell seeding efficiency as well as uniformity of cell distribution… read more here.
Keywords: macro scale; cell; perfusion; engineering ... See more keywords
Cell‐controlled hybrid perfusion fed‐batch CHO cell process provides significant productivity improvement over conventional fed‐batch cultures
Sign Up to like & getrecommendations! Published in 2017 at "Biotechnology and Bioengineering"
DOI: 10.1002/bit.26259
Abstract: A simple method originally designed to control lactate accumulation in fed‐batch cultures of Chinese Hamster Ovary (CHO) cells has been modified and extended to allow cells in culture to control their own rate of perfusion… read more here.
Keywords: perfusion; batch cultures; fed batch; batch ... See more keywords
Perfusion applied to a 3D model of bone metastasis results in uniformly dispersed mechanical stimuli
Sign Up to like & getrecommendations! Published in 2018 at "Biotechnology and Bioengineering"
DOI: 10.1002/bit.26524
Abstract: Breast cancer most frequently metastasizes to the skeleton. Bone metastatic cancer is incurable and induces wide‐spread bone osteolysis, resulting in significant patient morbidity and mortality. Mechanical cues in the skeleton are an important microenvironmental parameter… read more here.
Keywords: model bone; perfusion; bone; model ... See more keywords
Perfusion cultures require optimum respiratory ATP supply to maximize cell‐specific and volumetric productivities
Sign Up to like & getrecommendations! Published in 2019 at "Biotechnology and Bioengineering"
DOI: 10.1002/bit.26926
Abstract: Perfusion processes are an emerging alternative to common fed‐batch processes in the growing biopharmaceutical industry. However, the challenge of maintaining high cell‐specific productivities remains. In this study, glucose limitation was applied to two perfusion steady… read more here.
Keywords: cell specific; respiratory atp; atp supply; perfusion ... See more keywords
Computational fluid dynamic analysis of bioprinted self‐supporting perfused tissue models
Sign Up to like & getrecommendations! Published in 2019 at "Biotechnology and Bioengineering"
DOI: 10.1002/bit.27238
Abstract: Natural tissues are incorporated with vasculature, which is further integrated with a cardiovascular system responsible for driving perfusion of nutrient‐rich oxygenated blood through the vasculature to support cell metabolism within most cell‐dense tissues. Since scaffold‐free… read more here.
Keywords: perfusion; tissue; perfused tissue; supporting perfused ... See more keywords
Virus harvesting in perfusion culture: Choosing the right type of hollow fiber membrane
Sign Up to like & getrecommendations! Published in 2020 at "Biotechnology and Bioengineering"
DOI: 10.1002/bit.27470
Abstract: The use of bioreactors coupled to membrane‐based perfusion systems enables very high cell and product concentrations in vaccine and viral vector manufacturing. Many virus particles, however, are not stable and either lose their infectivity or… read more here.
Keywords: perfusion; membrane; hollow fiber; filter fouling ... See more keywords