Impact of micro and macroporous TFF membranes on product sieving and chromatography loading for perfusion cell culture
Sign Up to like & getrecommendations! Published in 2019 at "Biotechnology and Bioengineering"
DOI: 10.1002/bit.27192
Abstract: Bioprocess intensification can be achieved through high cell density perfusion cell culture with continuous protein capture integration. Protein passage and cell retention are commonly accomplished using tangential flow filtration systems consisting of microporous membranes. Significant… read more here.
Keywords: product sieving; chromatography; cell culture; perfusion cell ... See more keywords
Perfusion cell culture for the production of conjugated recombinant fusion proteins reduces clipping and quality heterogeneity compared to batch-mode processes.
Sign Up to like & getrecommendations! Published in 2019 at "Journal of biotechnology"
DOI: 10.1016/j.jbiotec.2019.06.006
Abstract: Perfusion cell culture technologies for the production of therapeuthic recombinant proteins are currently on the rise for diverse applications with the aim of process intensification (Bielser et al., 2018; Chen et al., 2018; Fisher et… read more here.
Keywords: quality; perfusion; cell culture; perfusion cell ... See more keywords
Development of a microfluidic perfusion 3D cell culture system
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Micromechanics and Microengineering"
DOI: 10.1088/1361-6439/aaa877
Abstract: Recently, 3-dimensional in vitro cell cultures have gained much attention in biomedical sciences because of the closer relevance between in vitro cell cultures and in vivo environments. This paper presents a microfluidic perfusion 3D cell… read more here.
Keywords: cell culture; perfusion cell; culture; cell ... See more keywords