Electrophysiological and ECG Effects of Perhexiline, A Mixed Cardiac Ion Channel Inhibitor, Evaluated in Non-clinical Assays and in Healthy Subjects.
Sign Up to like & getrecommendations! Published in 2021 at "Journal of clinical pharmacology"
DOI: 10.1002/jcph.1934
Abstract: Perhexiline has been used to treat hypertrophic cardiomyopathy. In addition to its effect on carnitine-palmitoyltransferase-1, it has mixed ion channel effects through inhibition of several cardiac ion currents. Effects on cardiac ion channels expressed in… read more here.
Keywords: perhexiline; ion channel; ecg effects; ion ... See more keywords
Perhexiline Demonstrates FYN-mediated Antitumor Activity in Glioblastoma
Sign Up to like & getrecommendations! Published in 2020 at "Molecular Cancer Therapeutics"
DOI: 10.1158/1535-7163.mct-19-1047
Abstract: Glioblastoma is the most common primary malignant brain tumor in adults. Despite aggressive treatment, outcomes remain poor with few long-term survivors. Therefore, considerable effort is being made to identify novel therapies for this malignancy. Targeting… read more here.
Keywords: treatment; perhexiline; glioblastoma; antitumor activity ... See more keywords
Proteomic characterisation of perhexiline treatment on THP-1 M1 macrophage differentiation
Sign Up to like & getrecommendations! Published in 2023 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2023.1054588
Abstract: Background Dysregulated inflammation is important in the pathogenesis of many diseases including cancer, allergy, and autoimmunity. Macrophage activation and polarisation are commonly involved in the initiation, maintenance and resolution of inflammation. Perhexiline (PHX), an antianginal… read more here.
Keywords: thp macrophage; phx; perhexiline; differentiation ... See more keywords
The Antianginal Drug Perhexiline Displays Cytotoxicity against Colorectal Cancer Cells In Vitro: A Potential for Drug Repurposing
Sign Up to like & getrecommendations! Published in 2022 at "Cancers"
DOI: 10.3390/cancers14041043
Abstract: Simple Summary Cancer cells frequently have an altered metabolism to support their increased proliferative and invasive activity. Perhexiline, a drug used to treat some cardiovascular diseases, inhibits some of the reported changes in the metabolism… read more here.
Keywords: cancer; perhexiline; colorectal cancer; treatment ... See more keywords