Overcoming peri- and ortho-selectivity in C–H methylation of 1-naphthaldehydes by a tunable transient ligand strategy
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DOI: 10.1039/d1sc05899a
Abstract: Methyl groups widely exist in bioactive molecules, and site-specific methylation has become a valuable strategy for their structural functionalization. Aiming to introduce this smallest alkyl handle, a highly regioselective peri- and ortho-C–H methylation of 1-naphthaldehyde… read more here.
Keywords: transient ligand; methylation; ligand strategy; strategy ... See more keywords