Darvadstrocel for the treatment of complex perianal fistulas
Sign Up to like & getrecommendations! Published in 2019 at "Prescriber"
DOI: 10.1002/psb.1804
Abstract: Darvadstrocel (Alofisel) – indicated for the treatment of complex perianal fistulas caused by Crohn's disease – is the first allogeneic stem‐cell therapy to be approved in the EU. This article examines its administration, efficacy and… read more here.
Keywords: darvadstrocel treatment; perianal fistulas; treatment complex; complex perianal ... See more keywords
Comparison of T2-weighted imaging, diffusion-weighted imaging and contrast-enhanced T1-weighted MR imaging for evaluating perianal fistulas.
Sign Up to like & getrecommendations! Published in 2017 at "Clinical imaging"
DOI: 10.1016/j.clinimag.2017.03.019
Abstract: PURPOSE To compare the lesion conspicuity and diagnostic performance of three imaging data sets (T2WI, combined T2WI and DWI [combined DWI], contrast-enhanced (CE)-T1WI) in assessing perianal fistulas. METHODS Two radiologists with 7 and 15years of… read more here.
Keywords: contrast enhanced; combined dwi; perianal fistulas; weighted imaging ... See more keywords
MR Imaging of Perianal Fistulas.
Sign Up to like & getrecommendations! Published in 2018 at "Radiologic clinics of North America"
DOI: 10.1016/j.rcl.2018.04.005
Abstract: In this article, we begin with an introduction of the perianal region anatomy, then review the definition, etiology, epidemiology, and 2 major classification systems of perianal fistulas. The role of MR imaging for assessment of… read more here.
Keywords: etiology; anatomy; epidemiology; imaging perianal ... See more keywords
DOP57 Predictive modelling to examine long term treatment effectiveness of darvadstrocel in patients with complex perianal fistulas in Crohn’s Disease
Sign Up to like & getrecommendations! Published in 2021 at "Journal of Crohn's and Colitis"
DOI: 10.1093/ecco-jcc/jjab073.096
Abstract: Darvadstrocel (DVS) was approved in 2018 by EMA for treatment of complex perianal fistulas in Crohn’s disease (CPF-CD)1, with evidence on long-term effectiveness still accruing. The objective of this study was to synthesize clinical trial… read more here.
Keywords: crohn; treatment; perianal fistulas; long term ... See more keywords
Long‐term efficacy of fibrin glue injection for perianal fistulas in patients with Crohn's disease
Sign Up to like & getrecommendations! Published in 2020 at "Colorectal Disease"
DOI: 10.1111/codi.15477
Abstract: The treatment of perianal fistulas in Crohn's disease remains challenging. Fibrin glue injection has previously shown short‐term efficacy in a randomized controlled trial. No long‐term data are available to assess the benefit of this treatment. read more here.
Keywords: term; disease; fibrin glue; perianal fistulas ... See more keywords
Ambulatory Surgery for Perianal Crohn's Disease: Study of Feasibility
Sign Up to like & getrecommendations! Published in 2018 at "Gastroenterology Research and Practice"
DOI: 10.1155/2018/5249087
Abstract: Background One-third of Crohn's disease (CD) patients present perianal fistula. The gold standard in the diagnosis and treatment of symptomatic perianal disease (PAD) in CD is the exploration of the anal canal and distal rectum… read more here.
Keywords: surgery; study; disease; perianal fistulas ... See more keywords
Evaluation of the Reliability and Quality of YouTube Video Content about Perianal Fistulas
Sign Up to like & getrecommendations! Published in 2022 at "BioMed Research International"
DOI: 10.1155/2022/2955273
Abstract: Objective Perianal fistulas of the perianal soft tissues are an important cause of morbidity and a significant portion of colorectal surgery. To our knowledge, there is no study evaluating YouTube videos pertaining perianal fistulas. In… read more here.
Keywords: quality; perianal fistulas; reliability; youtube video ... See more keywords
Darvadstrocel for the treatment of patients with perianal fistulas in Crohn's disease.
Sign Up to like & getrecommendations! Published in 2019 at "Drugs of today"
DOI: 10.1358/dot.2019.55.2.2914336
Abstract: Despite significant advances in medical and surgical therapy for perianal fistulas in Crohn's disease (CD), treatment results are still modest, and a specific need for more effective therapies is a reality. Darvadstrocel is composed of… read more here.
Keywords: treatment; disease; perianal fistulas; therapy ... See more keywords
Stem Cell Injection for Complex Refractory Perianal Fistulas in Crohn's Disease: A Single Center Initial Experience
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Surgery"
DOI: 10.3389/fsurg.2022.834870
Abstract: From 30 to 70% of patients with Crohn's disease (CD) may develop perianal fistulas during their lifetime. The medical and surgical management of this complication is challenging, and its treatment still gives unsatisfactory results. However,… read more here.
Keywords: disease; perianal fistulas; crohn disease; stem ... See more keywords
Non-Healing Perianal Fistulas: A Clinical Model of Tissue Senescence Impairing Both Tissue Fibrosis and Regenerative Potential
Sign Up to like & getrecommendations! Published in 2023 at "Biomedicines"
DOI: 10.3390/biomedicines11020537
Abstract: Senescent cells and fibrosis are important components that impact the regenerative capacity of skin, particularly when considering chronic non-healing wounds. Anoderm and perianal fistulas in the setting of Crohn’s disease are clinically pathophysiological extremes with… read more here.
Keywords: non healing; healing perianal; perianal fistulas; senescence ... See more keywords
Relationship between clinical remission of perianal fistulas in Crohn’s disease and serum adalimumab concentrations: A multi-center cross-sectional study
Sign Up to like & getrecommendations! Published in 2022 at "World Journal of Gastroenterology"
DOI: 10.3748/wjg.v28.i9.961
Abstract: BACKGROUND Crohn’s disease (CD) is complicated by perianal fistulas in approximately 20% of patients. Achieving permanent fistula closure remains a challenge for physicians. An association between serum anti-tumor necrosis factor-α concentrations and clinical outcomes in… read more here.
Keywords: clinical remission; ada concentrations; perianal fistulas; remission ... See more keywords