Overexpression of BDNF in the ventrolateral periaqueductal gray regulates the behavior of epilepsy–migraine comorbid rats
Sign Up to like & getrecommendations! Published in 2022 at "Brain and Behavior"
DOI: 10.1002/brb3.2594
Abstract: To investigate the effects of brain‐derived neurotrophic factor (BDNF) overexpression in the ventrolateral periaqueductal gray (vlPAG) on behavioral changes in epilepsy–migraine comorbid rats. read more here.
Keywords: periaqueductal gray; comorbid rats; epilepsy migraine; ventrolateral periaqueductal ... See more keywords
Sex‐specific cannabinoid 1 receptors on GABAergic neurons in the ventrolateral periaqueductal gray mediate analgesia in mice
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Comparative Neurology"
DOI: 10.1002/cne.25334
Abstract: Sex differences in analgesic effects have gradually attracted public attention in preclinical and clinical studies. Both human and animal females are more sensitive to cannabinoid antinociception than males. Expression of the cannabinoid 1 receptor (CB1R)… read more here.
Keywords: periaqueductal gray; cb1rs vlpag; ventrolateral periaqueductal; sex ... See more keywords
The regulatory role of nitric oxide in morphine‐induced analgesia in the descending path of pain from the dorsal hippocampus to the dorsolateral periaqueductal gray
Sign Up to like & getrecommendations! Published in 2022 at "European Journal of Pain"
DOI: 10.1002/ejp.1916
Abstract: Nitric oxide (NO) levels in brain nuclei, such as the hippocampus and brainstem, are involved in morphine analgesia, but the relationship between the dorsal hippocampus (dH) and the dorsolateral periaqueductal gray matter (dlPAG) needs to… read more here.
Keywords: periaqueductal gray; analgesia; dorsolateral periaqueductal; dorsal hippocampus ... See more keywords
Influence of periaqueductal gray on other salience network nodes predicts social sensitivity
Sign Up to like & getrecommendations! Published in 2022 at "Human Brain Mapping"
DOI: 10.1002/hbm.25751
Abstract: The intrinsic connectivity of the salience network (SN) plays an important role in social behavior, however the directional influence that individual nodes have on each other has not yet been fully determined. In this study,… read more here.
Keywords: periaqueductal gray; sensitivity; salience network; output ... See more keywords
Impaired visceral pain-related functions of the midbrain periaqueductal gray in rats with colitis
Sign Up to like & getrecommendations! Published in 2022 at "Brain Research Bulletin"
DOI: 10.1016/j.brainresbull.2022.02.002
Abstract: The midbrain periaqueductal gray (PAG) is a key structure involved in the supraspinal modulation of pain. Previous studies have reported the association of gut inflammation-triggered chronic abdominal pain with structural and neuronal alterations within the… read more here.
Keywords: visceral pain; midbrain periaqueductal; periaqueductal gray; pain ... See more keywords
The role of the periaqueductal gray in escape behavior
Sign Up to like & getrecommendations! Published in 2020 at "Current Opinion in Neurobiology"
DOI: 10.1016/j.conb.2019.11.014
Abstract: Escape behavior is a defensive action deployed by animals in response to imminent threats. In mammalian species, a variety of different brain circuits are known to participate in this crucial survival behavior. One of these… read more here.
Keywords: escape; role periaqueductal; periaqueductal gray; gray escape ... See more keywords
Activation orexin 1 receptors in the ventrolateral periaqueductal gray matter attenuate nitroglycerin-induced migraine attacks and calcitonin gene related peptide up-regulation in trigeminal nucleus caudalis of rats
Sign Up to like & getrecommendations! Published in 2020 at "Neuropharmacology"
DOI: 10.1016/j.neuropharm.2020.107981
Abstract: This study aims to explore whether orexin 1 receptors (Orx1R) in the ventrolateral periaqueductal gray matter (vlPAG) play a role in the modulation of migraine headaches in adult male Wistar rats. To model chronic migraine-associated… read more here.
Keywords: orexin receptors; ventrolateral periaqueductal; gray matter; periaqueductal gray ... See more keywords
Nitric oxide in the dorsal periaqueductal gray mediates the panic-like escape response evoked by exposure to hypoxia
Sign Up to like & getrecommendations! Published in 2019 at "Progress in Neuro-Psychopharmacology and Biological Psychiatry"
DOI: 10.1016/j.pnpbp.2019.02.003
Abstract: &NA; Exposure of rats to an environment with low O2 levels evokes a panic‐like escape behavior and recruits the dorsal periaqueductal gray (dPAG), which is considered to be a key region in the pathophysiology of… read more here.
Keywords: response; escape; dorsal periaqueductal; exposure ... See more keywords
GABAergic basal forebrain projections to the periaqueductal gray promote food consumption, reward and predation
Sign Up to like & getrecommendations! Published in 2021 at "Scientific Reports"
DOI: 10.1038/s41598-021-02157-7
Abstract: Behaviors central to the procurement and consumption of food are among those most fundamental to survival, but their inappropriate expression can lead to overeating and obesity. Nevertheless, we have a poor understanding of circuits that… read more here.
Keywords: projections periaqueductal; periaqueductal gray; basal forebrain; consumption ... See more keywords
Activity in a prefrontal-periaqueductal gray circuit overcomes behavioral and endocrine features of the passive coping stress response
Sign Up to like & getrecommendations! Published in 2022 at "Proceedings of the National Academy of Sciences of the United States of America"
DOI: 10.1073/pnas.2210783119
Abstract: Significance The question of how the brain links behavioral and biological features of defensive stress responses has remained elusive. Here, we show that active stress-coping behavior in rats is associated with activity increases along a… read more here.
Keywords: periaqueductal gray; stress; gray circuit; circuit ... See more keywords
Periaqueductal gray matter and medial prefrontal cortex reflect negative prediction errors during differential conditioning.
Sign Up to like & getrecommendations! Published in 2023 at "Social cognitive and affective neuroscience"
DOI: 10.1093/scan/nsad025
Abstract: Computational models of associative learning posit that negative prediction errors arising from the omission of aversive outcomes weaken aversive Pavlovian associations during differential conditioning and extinction. It is possible that negative prediction errors may underlie… read more here.
Keywords: periaqueductal gray; prediction errors; negative prediction; differential conditioning ... See more keywords