The chromatin remodeler RSC prevents ectopic CENP-A propagation into pericentromeric heterochromatin at the chromatin boundary
Sign Up to like & getrecommendations! Published in 2022 at "Nucleic Acids Research"
DOI: 10.1093/nar/gkac827
Abstract: Abstract Centromeres of most eukaryotes consist of two distinct chromatin domains: a kinetochore domain, identified by the histone H3 variant, CENP-A, and a heterochromatic domain. How these two domains are separated is unclear. Here, we… read more here.
Keywords: heterochromatin; pericentromeric heterochromatin; chromatin; remodeler rsc ... See more keywords
Remodeling and destabilization of chromosome 1 pericentromeric heterochromatin by SSX proteins
Sign Up to like & getrecommendations! Published in 2019 at "Nucleic Acids Research"
DOI: 10.1093/nar/gkz396
Abstract: Abstract Rearrangement of the 1q12 pericentromeric heterochromatin and subsequent amplification of the 1q arm is commonly associated with cancer development and progression and may result from epigenetic deregulation. In many premalignant and malignant cells, loss… read more here.
Keywords: heterochromatin; 1q12 pericentromeric; pericentromeric heterochromatin; ssx proteins ... See more keywords