Transcriptomics analysis of pericytes from retinas of diabetic animals reveals novel genes and molecular pathways relevant to blood-retinal barrier alterations in diabetic retinopathy.
Sign Up to like & getrecommendations! Published in 2020 at "Experimental eye research"
DOI: 10.1016/j.exer.2020.108043
Abstract: Selective pericyte loss, the histological hallmark of early diabetic retinopathy (DR), enhances the breakdown of the blood-retinal barrier (BRB) in diabetes. However, the role of pericytes on BRB alteration in diabetes and the signaling pathways… read more here.
Keywords: retinal barrier; diabetic retinopathy; blood retinal; analysis ... See more keywords
Pericyte implantation in the brain enhances cerebral blood flow and reduces amyloid-β pathology in amyloid model mice
Sign Up to like & getrecommendations! Published in 2018 at "Experimental Neurology"
DOI: 10.1016/j.expneurol.2017.10.023
Abstract: ABSTRACT Pericytes are a major component of cerebrovasculature playing a key role in maintaining cerebrovascular homeostasis. These cells have also been suggested to regulate brain metabolism of amyloid‐&bgr; (A&bgr;), disturbances of which are believed to… read more here.
Keywords: bgr; pathology; pericyte; implantation ... See more keywords
Impairment of pericyte-endothelium crosstalk leads to blood-brain barrier dysfunction following traumatic brain injury
Sign Up to like & getrecommendations! Published in 2019 at "Experimental Neurology"
DOI: 10.1016/j.expneurol.2019.03.014
Abstract: The blood-brain barrier (BBB) constitutes a neurovascular unit formed by microvascular endothelial cells, pericytes, and astrocytes. Brain pericytes are important regulators of BBB integrity, permeability, and blood flow. Pericyte loss has been implicated in injury;… read more here.
Keywords: pericyte endothelium; brain; blood; pericyte ... See more keywords
Ang-1 and Ang-2 expression in angiomyolipoma and PEComa family tumors.
Sign Up to like & getrecommendations! Published in 2017 at "Journal of orthopaedics"
DOI: 10.1016/j.jor.2016.12.001
Abstract: OBJECTIVE Perivascular epithelioid cell tumors (PEComa) are an uncommon family of soft tissue tumors. Previously, we described that the presence of pericyte antigens among PEComa family tumors differs extensively by histologic appearance. METHODS Here, we… read more here.
Keywords: ang ang; family tumors; family; pecoma family ... See more keywords
Novel Mechanism of the Pericyte-Myofibroblast Transition in Renal Interstitial Fibrosis: Core Fucosylation Regulation
Sign Up to like & getrecommendations! Published in 2017 at "Scientific Reports"
DOI: 10.1038/s41598-017-17193-5
Abstract: Pericytes have been identified as a major source of myofibroblasts in renal interstitial fibrosis (RIF). The overactivation of several signaling pathways, mainly the TGF-β and PDGF pathways, initiates the pericyte-myofibroblast transition during RIF. Key receptors… read more here.
Keywords: transition; core fucosylation; fucosylation; pericyte ... See more keywords
186 Reduced pericyte insulin signalling causes abnormal developmental angiogenesis
Sign Up to like & getrecommendations! Published in 2017 at "Heart"
DOI: 10.1136/heartjnl-2017-311726.184
Abstract: Introduction Microvascular endothelial cells (ECs) are surrounded and supported by mural cells called pericytes. Via paracrine signalling and gap junctions, pericytes interact with ECs, modulating angiogenesis and vessel homeostasis. Diabetes-associated vascular complications are characterised by… read more here.
Keywords: insulin signalling; insulin; angiogenesis; pericyte ... See more keywords
Abstract 3850: Aberrant tumor pericytes in pancreatic ductal adenocarcinoma-a barrier and opportunity for therapeutic advances
Sign Up to like & getrecommendations! Published in 2025 at "Cancer Research"
DOI: 10.1158/1538-7445.am2025-3850
Abstract: There is a lack of effective treatment for PDAC, often due to abnormal and leaky blood vessels and a lack of proper pericyte coverage, contributing to the inability of the drugs to reach the tumor.… read more here.
Keywords: tumor pericytes; pericyte; tumor associated; tumor ... See more keywords
Pericyte Progenitor Coupling to the Emerging Endothelium During Vasculogenesis via Connexin 43
Sign Up to like & getrecommendations! Published in 2022 at "Arteriosclerosis, Thrombosis, and Vascular Biology"
DOI: 10.1161/atvbaha.121.317324
Abstract: Background: Vascular pericytes stabilize blood vessels and contribute to their maturation, while playing other key roles in microvascular function. Nevertheless, relatively little is known about involvement of their precursors in the earliest stages of vascular… read more here.
Keywords: cx43 gja1; cell; vasculogenesis; pericyte ... See more keywords
Dual role of pericyte α6β1-integrin in tumour blood vessels
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Cell Science"
DOI: 10.1242/jcs.197848
Abstract: ABSTRACT The α6β1-integrin is a major laminin receptor, and formation of a laminin-rich basement membrane is a key feature in tumour blood vessel stabilisation and pericyte recruitment, processes that are important in the growth and… read more here.
Keywords: tumour blood; blood vessel; integrin; blood ... See more keywords
Microvascular Homeostasis Is Compromised in Pancreatic Islets in a Mouse Model of β-Cell Loss and Low-Grade Inflammation.
Sign Up to like & getrecommendations! Published in 2025 at "Diabetes"
DOI: 10.2337/db25-0368
Abstract: Vascular dysfunction is considered a consequence of diabetes. However, in pancreatic islets, some hemodynamic changes occur before the onset of symptoms. The underlying mechanisms driving islet vascular abnormalities have not been fully characterized, but islet… read more here.
Keywords: loss; pericyte; cell; islet ... See more keywords
Pathological pericyte expansion and impaired endothelial cell-pericyte communication in endothelial Rbpj deficient brain arteriovenous malformation
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Human Neuroscience"
DOI: 10.3389/fnhum.2022.974033
Abstract: Pericytes, like vascular smooth muscle cells, are perivascular cells closely associated with blood vessels throughout the body. Pericytes are necessary for vascular development and homeostasis, with particularly critical roles in the brain, where they are… read more here.
Keywords: rbpj; communication; brain; pericyte ... See more keywords