Activation of Sigma-1 Receptor Enhanced Pericyte Survival via the Interplay Between Apoptosis and Autophagy: Implications for Blood–Brain Barrier Integrity in Stroke
Sign Up to like & getrecommendations! Published in 2019 at "Translational Stroke Research"
DOI: 10.1007/s12975-019-00711-0
Abstract: Stroke is a cerebrovascular disorder that affects many people worldwide. Pericytes play an important role in stroke progression and recovery. The sigma-1 receptor (σ-1R) signaling pathway has been suggested as having promising neuroprotective potential in… read more here.
Keywords: apoptosis; apoptosis autophagy; pericyte survival; sigma receptor ... See more keywords
Interleukin-4 prevents increased endothelial permeability by inducing pericyte survival and modulating microglial responses in diabetic retinopathy
Sign Up to like & getrecommendations! Published in 2025 at "Frontiers in Endocrinology"
DOI: 10.3389/fendo.2025.1609796
Abstract: Introduction Retinal vascular leakage due to increased endothelial permeability is a major contributor to the pathogenesis of diabetic retinopathy (DR) and visual impairment. Pericyte loss and microglia-mediated inflammation exacerbate this vascular dysfunction. Interleukin-4 (IL-4) is… read more here.
Keywords: endothelial permeability; modulating microglial; pericyte survival; increased endothelial ... See more keywords