Biosynthesis of (R)‐(+)‐perillyl alcohol by Escherichia coli expressing neryl pyrophosphate synthase
Sign Up to like & getrecommendations! Published in 2022 at "Engineering in Life Sciences"
DOI: 10.1002/elsc.202100135
Abstract: (R)‐(+)‐perillyl alcohol is widely used in agricultural and anticarcinogenic fields. Microbial production of (R)‐(+)‐perillyl alcohol was investigated in this study. We optimized biosynthesis of (R)‐(+)‐perillyl alcohol in Escherichia coli by using neryl pyrophosphate synthase and… read more here.
Keywords: perillyl alcohol; neryl pyrophosphate; coli; perillyl ... See more keywords
Limonene, a food additive, and its active metabolite perillyl alcohol improve regeneration and attenuate neuropathic pain after peripheral nerve injury: Evidence for IL-1β, TNF-α, GAP, NGF and ERK involvement.
Sign Up to like & getrecommendations! Published in 2020 at "International immunopharmacology"
DOI: 10.1016/j.intimp.2020.106766
Abstract: BACKGROUND Limonene (LIM) and its main metabolite perillyl alcohol (POH) are ingredients found in food with promising chemical entities due to their pharmacological profile. In this study, we hypothesized that LIM and POH are two… read more here.
Keywords: gap; metabolite perillyl; perillyl alcohol; neuropathic pain ... See more keywords
Perillyl Alcohol Attenuates NLRP3 Inflammasome Activation and Rescues Dopaminergic Neurons in Experimental In Vitro and In Vivo Models of Parkinson's Disease.
Sign Up to like & getrecommendations! Published in 2021 at "ACS chemical neuroscience"
DOI: 10.1021/acschemneuro.1c00550
Abstract: NLRP3 activation plays a key role in the initiation and progression of a variety of neurodegenerative diseases. However, understanding the molecular mechanisms involved in the bidirectional signaling required to activate the NLRP3 inflammasomes is the… read more here.
Keywords: inflammasome activation; vitro vivo; nlrp3 inflammasome; vivo models ... See more keywords
Controlled Release of Perillyl Alcohol via pH-Responsive Chitosan-Polypyrrole Nanocarriers
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DOI: 10.1021/acsomega.5c04817
Abstract: This work focused on developing CS/PPy, a pH-responsive controlled-release nanocarrier composed of natural polymer, the chitosan (CS), and synthetic polymer, the polypyrrole (PPy). The goal was to evaluate its potential application in controlled release studies… read more here.
Keywords: perillyl alcohol; polypyrrole; release; controlled release ... See more keywords
Efficient Synthesis of (R)-(+)-Perillyl Alcohol From (R)-(+)-Limonene Using Engineered Escherichia coli Whole Cell Biocatalyst
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Bioengineering and Biotechnology"
DOI: 10.3389/fbioe.2022.900800
Abstract: (R)-(+)-perillyl alcohol is a much valued supplemental compound with a wide range of agricultural and pharmacological characteristics. The aim of this study was to improve (R)-(+)-perillyl alcohol production using a whole-cell catalytic formula. In this… read more here.
Keywords: perillyl alcohol; whole cell; biocatalyst; alcohol ... See more keywords
Hydrocinnamic Acid and Perillyl Alcohol Potentiate the Action of Antibiotics against Escherichia coli
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DOI: 10.3390/antibiotics12020360
Abstract: The treatment of bacterial infections has been troubled by the increased resistance to antibiotics, instigating the search for new antimicrobial therapies. Phytochemicals have demonstrated broad-spectrum and effective antibacterial effects as well as antibiotic resistance-modifying activity.… read more here.
Keywords: hydrocinnamic acid; escherichia coli; perillyl alcohol;
Perillyl Alcohol and Perillic Acid Exert Efficient Action upon HSV-1 Maturation and Release of Infective Virus
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DOI: 10.3851/imp3315
Abstract: Background Infection by herpes simplex type-1 virus (HSV-1) causes several pathological processes, including cutaneous, oral and genital infections, fatal encephalitis and cognitive dysfunction due to grey matter loss. Acyclovir is the reference compound used as… read more here.
Keywords: action upon; release infective; action; hsv maturation ... See more keywords