Astragalin attenuates depression-like behaviors and memory deficits and promotes M2 microglia polarization by regulating IL-4R/JAK1/STAT6 signaling pathway in a murine model of perimenopausal depression.
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DOI: 10.1007/s00213-022-06133-5
Abstract: RATIONALE Neuroinflammation can be alleviated via M2 microglia polarization, which could promote the recovery of perimenopausal depression. Astragalin (AST) possesses anti-neuroinflammatory activity. However, the effects of AST on perimenopausal depression and the molecular mechanism in… read more here.
Keywords: model; depression; microglia polarization; perimenopausal depression ... See more keywords
Assessment of perimenopausal depression: A review.
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DOI: 10.1016/j.jad.2019.02.029
Abstract: BACKGROUND Within the female life cycle, the perimenopause is considered as a critical period for the development of depression. Prevalence rates are particularly high during this phase. Perimenopausal depression is characterized by affective symptoms as… read more here.
Keywords: depression; assessment perimenopausal; perimenopausal depression; mood ... See more keywords
Pharmacotherapeutic approaches to treating depression during the perimenopause
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DOI: 10.1080/14656566.2019.1645122
Abstract: ABSTRACT Introduction: Although postnatal depression is now well recognized, there is also a risk of depressive symptoms during perimenopause. The mechanisms underlying perimenopausal depression are still poorly understood; however, there are available treatment options. Areas… read more here.
Keywords: pharmacotherapeutic approaches; depression; perimenopausal depression; treatment ... See more keywords
Neuroprotective Effects of Estrogen Through BDNF-Transient Receptor Potential Channels 6 Signaling Pathway in the Hippocampus in a Rat Model of Perimenopausal Depression
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DOI: 10.3389/fnagi.2022.869274
Abstract: Estradiol (E2) has been proven to be effective in treating perimenopausal depression (PD); however, the downstream signaling pathways have not been fully elucidated. Transient receptor potential channels 6 (TRPC6) plays a vital role in promoting… read more here.
Keywords: perimenopausal depression; rat; transient receptor; receptor potential ... See more keywords