Microglial dyshomeostasis drives perineuronal net and synaptic loss in a CSF1R+/− mouse model of ALSP, which can be rescued via CSF1R inhibitors
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DOI: 10.1126/sciadv.abg1601
Abstract: Microglia dyshomeostasis induces pathology in CSF1R+/− mice, which can be reduced with pharmacological CSF1R inhibition. read more here.
Keywords: drives perineuronal; csf1r; microglial dyshomeostasis; perineuronal net ... See more keywords
High Iron and Iron Household Protein Contents in Perineuronal Net-Ensheathed Neurons Ensure Energy Metabolism with Safe Iron Handling
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DOI: 10.3390/ijms23031634
Abstract: A subpopulation of neurons is less vulnerable against iron-induced oxidative stress and neurodegeneration. A key feature of these neurons is a special extracellular matrix composition that forms a perineuronal net (PN). The PN has a… read more here.
Keywords: metabolism; ensheathed neurons; iron iron; iron handling ... See more keywords