Discovery and Optimization of Pyrrolopyrimidine Derivatives as Selective Disruptors of the Perinucleolar Compartment, a Marker of Tumor Progression toward Metastasis.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of medicinal chemistry"
DOI: 10.1021/acs.jmedchem.2c00204
Abstract: The perinucleolar compartment (PNC) is a dynamic subnuclear body found at the periphery of the nucleolus. The PNC is enriched with RNA transcripts and RNA-binding proteins, reflecting different states of genome organization. PNC prevalence positively… read more here.
Keywords: marker; perinucleolar compartment; progression; pnc ... See more keywords
Perinucleolar Compartment (PNC) Prevalence as an Independent Prognostic Factor in Pediatric Ewing Sarcoma: A Multi-Institutional Study
Sign Up to like & getrecommendations! Published in 2023 at "Cancers"
DOI: 10.3390/cancers15082230
Abstract: Simple Summary The perinucleolar compartment (PNC) plays an important role in tumorigenesis. Its presence has been correlated with poor prognosis and cancer metastasis. Ewing sarcoma (EWS) is the second most common bone cancer in children… read more here.
Keywords: ewing sarcoma; perinucleolar compartment; prevalence; pnc prevalence ... See more keywords