Reversal of apixaban anticoagulation by four‐factor prothrombin complex concentrates in healthy subjects: a randomized three‐period crossover study
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Thrombosis and Haemostasis"
DOI: 10.1111/jth.13815
Abstract: Essentials Prothrombin complex concentrates (PCCs) may reverse the effect of factor Xa (FXa) inhibitors. We conducted an open‐label, randomized, placebo‐controlled, three‐period crossover study in 15 subjects. Both PCCs rapidly reversed apixaban‐mediated decreases in mean endogenous… read more here.
Keywords: period crossover; crossover study; three period; complex concentrates ... See more keywords
239-OR: A Phase 1, Randomized, Double-Blind, Placebo-Controlled, Four-Period, Crossover Trial to Assess the Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of Three Dose Levels of PB201 as Monotherapy in Subjects with Type 2 Diabetes Mellitus
Sign Up to like & getrecommendations! Published in 2021 at "Diabetes"
DOI: 10.2337/db21-239-or
Abstract: Background: PB201, a dual-acting glucokinase activator (GKA), increases glucose stimulated insulin secretion, promotes glycogen synthesis and reduces hepatic glucose output by targeting both pancreatic and hepatic glucokinase. As a partial GKA, PB201 maintains efficacy while… read more here.
Keywords: dose levels; levels pb201; period; period crossover ... See more keywords