Preparation and quality by design assisted (Qb-d) optimization of bioceramic loaded microspheres for periodontal delivery of doxycycline hyclate
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DOI: 10.1016/j.sjbs.2021.03.046
Abstract: PLGA (Lactic- co-glycolic acid) coated chitosan microspheres loaded with hydroxyapatite and doxycycline hyclate complex were developed in the present study for periodontal delivery. A modified single emulsion method was adopted for the development of microspheres.… read more here.
Keywords: doxycycline hyclate; delivery; quality design; design assisted ... See more keywords