Monocyte NLRP3-IL-1β Hyperactivation Mediates Neuronal and Synaptic Dysfunction in Perioperative Neurocognitive Disorder.
Sign Up to like & getrecommendations! Published in 2022 at "Advanced science"
DOI: 10.1002/advs.202104106
Abstract: Perioperative neurocognitive disorder may develop in vulnerable patients following major operation. While neuroinflammation is linked to the cognitive effects of surgery, how surgery and immune signaling modulate neuronal circuits, leading to learning and memory impairment… read more here.
Keywords: surgery; perioperative neurocognitive; neurocognitive disorder; neuronal synaptic ... See more keywords
The Evolving Role of Specialized Pro-resolving Mediators in Modulating Neuroinflammation in Perioperative Neurocognitive Disorders.
Sign Up to like & getrecommendations! Published in 2019 at "Advances in experimental medicine and biology"
DOI: 10.1007/978-3-030-21735-8_4
Abstract: Surgery can be a life-saving procedure; however, significant complications may occur after routine procedures especially in older and more frail patients. Perioperative neurocognitive disorders (PNDs), including delirium and postoperative cognitive dysfunction, are the most common… read more here.
Keywords: specialized pro; perioperative neurocognitive; pro resolving; role ... See more keywords
Anthocyanins attenuate neuroinflammation through the suppression of MLK3 activation in a mouse model of perioperative neurocognitive disorders
Sign Up to like & getrecommendations! Published in 2020 at "Brain Research"
DOI: 10.1016/j.brainres.2019.146504
Abstract: Perioperative neurocognitive disorder (PND) is a common complication that lacks effective prevention and treatment measures. Neuroinflammation is considered to be one of the important mechanisms of PND. In this study, we investigated the effect and… read more here.
Keywords: anthocyanins attenuate; mlk3; perioperative neurocognitive; neuroinflammation ... See more keywords
Gastrodin alleviates perioperative neurocognitive dysfunction of aged mice by suppressing neuroinflammation.
Sign Up to like & getrecommendations! Published in 2020 at "European journal of pharmacology"
DOI: 10.1016/j.ejphar.2020.173734
Abstract: Perioperative neurocognitive disorder (PND) is a common complication of elderly patients after surgery and lacks effective prevention and treatment measures. We investigated the effect and mechanism of gastrodin (GAS), a natural plant ingredient, on postoperative… read more here.
Keywords: surgery; perioperative neurocognitive; mice subjected; gas ... See more keywords
Risk assessment of perioperative neurocognitive disorders, where are we now?
Sign Up to like & getrecommendations! Published in 2022 at "Current Opinion in Anaesthesiology"
DOI: 10.1097/aco.0000000000001120
Abstract: Purpose of review Perioperative neurocognitive disorders (PNDs) are among the most frequent complications after surgery and are associated with considerable morbidity and mortality. We analysed the recent literature regarding risk assessment of PND. Recent findings… read more here.
Keywords: anaesthesiology; neurocognitive disorders; risk assessment; perioperative neurocognitive ... See more keywords
Intergenerational Perioperative Neurocognitive Disorder in Young Adult Male Rats with Traumatic Brain Injury
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DOI: 10.1097/aln.0000000000004496
Abstract: Background: The authors tested the hypothesis that the effects of traumatic brain injury, surgery, and sevoflurane interact to induce neurobehavioral abnormalities in adult male rats and in their offspring (an animal model of intergenerational perioperative… read more here.
Keywords: traumatic brain; brain; male rats; brain injury ... See more keywords
Identification of perioperative neurocognitive dysfunction biomarkers in cerebrospinal fluid with quantitative proteomic approach in patients undergoing transurethral resection of prostate with combined spinal and epidural analgesia
Sign Up to like & getrecommendations! Published in 2022 at "Medicine"
DOI: 10.1097/md.0000000000030448
Abstract: Background: This study aimed to identify predictive biomarkers of perioperative neurocognitive dysfunction (PND) in cerebrospinal fluid of elderly male patients undergoing elective transurethral resection of prostate, using an isobaric tags for relative and absolute quantitative-based… read more here.
Keywords: cerebrospinal fluid; pnd; proteomic approach; perioperative neurocognitive ... See more keywords
Transcutaneous electrical acupoint stimulation for the prevention of perioperative neurocognitive disorders in geriatric patients: A systematic review and meta-analysis of randomized controlled trials
Sign Up to like & getrecommendations! Published in 2022 at "Medicine"
DOI: 10.1097/md.0000000000032329
Abstract: Background: To evaluate whether transcutaneous electrical acupoint stimulation (TEAS) decreases rates of perioperative neurocognitive disorders (PND) when used as an adjuvant method during perioperative period in geriatric patients since the new definition was released in… read more here.
Keywords: electrical acupoint; transcutaneous electrical; analysis; acupoint stimulation ... See more keywords
Differential hippocampal protein expression between normal mice and mice with the perioperative neurocognitive disorder: a proteomic analysis
Sign Up to like & getrecommendations! Published in 2021 at "European Journal of Medical Research"
DOI: 10.1186/s40001-021-00599-3
Abstract: Objectives To compare differential expression protein in hippocampal tissues from mice of perioperative neurocognitive disorder (PND) and normal control mice and to explore the possible mechanism of PND. Methods Mice were randomly divided into a… read more here.
Keywords: perioperative neurocognitive; neurocognitive disorder; mice perioperative; expression ... See more keywords
Perioperative Neurocognitive Screening Tools for At-Risk Surgical Patients
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DOI: 10.1212/cpj.0000000000001132
Abstract: Perioperative neurocognitive disorders are common following surgery and have serious socioeconomic impacts. Despite this, these disorders remain under recognized and underdiagnosed. To facilitate detection and direct patients towards appropriate preventative interventions, assessment of cognition during… read more here.
Keywords: risk surgical; perioperative neurocognitive; screening tools; surgical patients ... See more keywords
A modified mouse model of perioperative neurocognitive disorders exacerbated by sleep fragmentation
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DOI: 10.1538/expanim.22-0053
Abstract: Aging is one of the greatest risk factors for postoperative cognitive dysfunction (POCD), also known as perioperative neurocognitive disorder (PND). Animal models of PND are usually induced in mice over 18 months of age, which… read more here.
Keywords: sleep fragmentation; pnd model; perioperative neurocognitive; model ... See more keywords