Engineered Chitosan‐Derived Nanocarrier for Efficient siRNA Delivery to Peripheral and Central Neurons
Sign Up to like & getrecommendations! Published in 2024 at "Advanced Healthcare Materials"
DOI: 10.1002/adhm.202500107
Abstract: Gene therapy using small interfering RNA (siRNA) holds promise for treating neurological disorders by silencing specific genes, such as the phosphatase and tensin homolog (PTEN) gene, which restricts axonal growth. Yet, delivering siRNA to neurons… read more here.
Keywords: delivery peripheral; sirna delivery; peripheral central; delivery ... See more keywords
Systematic review and co‐ordinate based meta‐analysis to summarize the utilization of functional brain imaging in conjunction with human models of peripheral and central sensitization
Sign Up to like & getrecommendations! Published in 2024 at "European Journal of Pain"
DOI: 10.1002/ejp.2251
Abstract: Functional magnetic resonance imaging, in conjunction with models of peripheral and/or central sensitization, has been used to assess analgesic efficacy in healthy humans. This review aims to summarize the use of these techniques to characterize… read more here.
Keywords: imaging conjunction; peripheral central; central sensitization; models peripheral ... See more keywords
296. Correlating Peripheral and Central Markers of Neuroinflammation to PET Imaging of Translocator Protein (TSPO)
Sign Up to like & getrecommendations! Published in 2017 at "Biological Psychiatry"
DOI: 10.1016/j.biopsych.2017.02.310
Abstract: stressed mice. However, CSD does not cause extravasation of peripheral monocytes into brain. Conclusions: CSD-S microglia are more phagocytic and secrete molecules that break down the BBB. These kinds of activities represent a CNS-centric inflammatory… read more here.
Keywords: 296 correlating; central markers; correlating peripheral; markers neuroinflammation ... See more keywords
Isoflurane aggravates peripheral and central insulin resistance in high-fat diet/streptozocin-induced type 2 diabetic mice
Sign Up to like & getrecommendations! Published in 2020 at "Brain Research"
DOI: 10.1016/j.brainres.2019.146511
Abstract: Isoflurane anesthesia is reported to induce insulin resistance (IR) in the peripheral tissues. However, researches on the impact of isoflurane on insulin-related metabolism in the central nervous system, especially in type 2 diabetes mellitus (T2DM),… read more here.
Keywords: insulin; isoflurane anesthesia; peripheral central; mice ... See more keywords
Echinodorus macrophyllus fraction with a high level of flavonoid inhibits peripheral and central mechanisms of nociception
Sign Up to like & getrecommendations! Published in 2021 at "Journal of Traditional and Complementary Medicine"
DOI: 10.1016/j.jtcme.2021.07.001
Abstract: Abstract Background and aim: Echinodorus macrophyllus (Kunth.) Micheli is popularly used for acute and chronic inflammatory conditions. The anti-inflammatory activity was previously demonstrated for its flavonoid-enriched fractions. The aim of this work assessed the antinociceptive… read more here.
Keywords: fr40; echinodorus; central mechanisms; nociception ... See more keywords
Tau associated peripheral and central neurodegeneration: Identification of an early imaging marker for tauopathy
Sign Up to like & getrecommendations! Published in 2021 at "Neurobiology of Disease"
DOI: 10.1016/j.nbd.2021.105273
Abstract: Pathological hyperphosphorylated tau is a key feature of Alzheimer's disease (AD) and Frontotemporal dementia (FTD). Using transgenic mice overexpressing human non-mutated tau (htau mice), we assessed the contribution of tau to peripheral and central neurodegeneration.… read more here.
Keywords: associated peripheral; tau; peripheral central; neurodegeneration ... See more keywords
Peripheral and Central Nutrient Sensing Underlying Appetite Regulation
Sign Up to like & getrecommendations! Published in 2018 at "Trends in Neurosciences"
DOI: 10.1016/j.tins.2018.05.003
Abstract: The precise regulation of fluid and energy homeostasis is essential for survival. It is well appreciated that ingestive behaviors are tightly regulated by both peripheral sensory inputs and central appetite signals. With recent neurogenetic technologies,… read more here.
Keywords: central nutrient; underlying appetite; sensing underlying; peripheral central ... See more keywords
BAT is independently affected by peripheral and central pathways
Sign Up to like & getrecommendations! Published in 2018 at "International Journal of Obesity"
DOI: 10.1038/ijo.2017.221
Abstract: International Journal of Obesity accepted article preview online, 08 September 2017. doi:10.1038/ijo.2017.221. read more here.
Keywords: peripheral central; affected peripheral; independently affected; central pathways ... See more keywords
Severe allo-immune antibody-associated peripheral and central nervous system diseases after allogeneic hematopoietic stem cell transplantation
Sign Up to like & getrecommendations! Published in 2021 at "Scientific Reports"
DOI: 10.1038/s41598-021-87989-z
Abstract: Allogeneic hematopoietic stem cell transplantation (alloHSCT) is a curative treatment for hematologic malignancies. Acute and chronic graft-versus-host disease (GvHD) are the major immune-mediated complications after alloHSCT. However, there is controversy whether neurologic complications after alloHSCT… read more here.
Keywords: immune; system; nervous system; central nervous ... See more keywords
LRRK2 in peripheral and central nervous system innate immunity: its link to Parkinson's disease
Sign Up to like & getrecommendations! Published in 2017 at "Biochemical Society Transactions"
DOI: 10.1042/bst20160262
Abstract: Mutations in the leucine-rich repeat kinase 2 (LRRK2) gene are found in familial and idiopathic cases of Parkinson's disease (PD), but are also associated with immune-related disorders, notably Crohn's disease and leprosy. Although the physiological… read more here.
Keywords: immunity; peripheral central; lrrk2 peripheral; parkinson disease ... See more keywords
Temporal relations between peripheral and central arousals in good and poor sleepers
Sign Up to like & getrecommendations! Published in 2022 at "Proceedings of the National Academy of Sciences of the United States of America"
DOI: 10.1073/pnas.2201143119
Abstract: Significance Arousals represent a fundamental property of the nervous system that enables organisms to perceive and properly respond to internal and external challenges. Arousal mechanisms are evident during wakefulness hours to mitigate external stressors and… read more here.
Keywords: poor sleepers; peripheral central; central peripheral; temporal relations ... See more keywords