Polyphosphoinositide-Binding Domains: Insights from Peripheral Membrane and Lipid-Transfer Proteins.
Sign Up to like & getrecommendations! Published in 2018 at "Advances in experimental medicine and biology"
DOI: 10.1007/5584_2018_288
Abstract: Within eukaryotic cells, biochemical reactions need to be organized on the surface of membrane compartments that use distinct lipid constituents to dynamically modulate the functions of integral proteins or influence the selective recruitment of peripheral… read more here.
Keywords: ppin; membrane lipid; transfer proteins; lipid transfer ... See more keywords
Exploring Phosphoinositide Binding Using Native Mass Spectrometry.
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DOI: 10.1007/978-1-0716-1142-5_11
Abstract: Phosphoinositides interact with proteins to fulfill various functions in the cell. In many cases, they specifically recruit peripheral membrane proteins to biological membranes. The analysis of their interactions with proteins is therefore essential for understanding… read more here.
Keywords: native mass; membrane proteins; mass spectrometry; mass ... See more keywords
Predicting protein–membrane interfaces of peripheral membrane proteins using ensemble machine learning
Sign Up to like & getrecommendations! Published in 2022 at "Briefings in Bioinformatics"
DOI: 10.1093/bib/bbab518
Abstract: Abstract Abnormal protein–membrane attachment is involved in deregulated cellular pathways and in disease. Therefore, the possibility to modulate protein–membrane interactions represents a new promising therapeutic strategy for peripheral membrane proteins that have been considered so… read more here.
Keywords: peripheral membrane; predicting protein; membrane proteins; machine learning ... See more keywords
Peripheral membrane proteins modulate stress tolerance by safeguarding cellulose synthases
Sign Up to like & getrecommendations! Published in 2022 at "Science Advances"
DOI: 10.1101/2022.05.24.493199
Abstract: Controlled primary cell wall remodeling adapts plant growth under stressful conditions, but how these changes are conveyed to adjust cellulose synthesis is unknown. Here, we identify the Tetratricopeptide Thioredoxin-Like (TTL) proteins as new members of… read more here.
Keywords: peripheral membrane; membrane proteins; modulate stress; stress tolerance ... See more keywords
Peripheral Membrane Proteins: Promising Therapeutic Targets across Domains of Life
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DOI: 10.3390/membranes11050346
Abstract: Membrane proteins can be classified into two main categories—integral and peripheral membrane proteins—depending on the nature of their membrane interaction. Peripheral membrane proteins are highly unique amphipathic proteins that interact with the membrane indirectly, using… read more here.
Keywords: membrane proteins; therapeutic targets; proteins promising; promising therapeutic ... See more keywords