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   Articles with "peripheral monocytes" as a keyword



Peripheral monocyte entry is required for alpha-Synuclein induced inflammation and Neurodegeneration in a model of Parkinson disease

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recommendations! Published in 2018 at "Experimental Neurology"

DOI: 10.1016/j.expneurol.2017.11.010

Abstract: ABSTRACT Accumulation of alpha‐synuclein (&agr;‐syn) in the central nervous system (CNS) is a core feature of Parkinson disease (PD) that leads to activation of the innate immune system, production of inflammatory cytokines and chemokines, and… read more here.

Keywords: agr syn; ccr2; neurodegeneration; parkinson disease ... See more keywords

Permanent neuroglial remodeling of the retina following infiltration of CSF1R inhibition-resistant peripheral monocytes

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recommendations! Published in 2018 at "Proceedings of the National Academy of Sciences of the United States of America"

DOI: 10.1073/pnas.1807123115

Abstract: Significance This work contributes to the understanding of the enigmatic progressive retinal damage following acute ocular surface injury. Clinical findings in patients suggest that such injuries can adversely affect the retina. This study demonstrates that… read more here.

Keywords: peripheral monocytes; infiltration; csf1r inhibition; injury ... See more keywords

Key Genes Associated With Functional Specialization of Neonatal Peripheral Monocytes

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recommendations! Published in 2025 at "Human Mutation"

DOI: 10.1155/humu/3009253

Abstract: Purpose: The purpose of this study is to identify genes and transcription factors underlying functional differences in neonatal versus adult peripheral blood monocytes, elucidating mechanisms of severe Group B streptococcus (GBS) infection in neonates. Methods:… read more here.

Keywords: peripheral monocytes; adult peripheral; rna seq; transcription ... See more keywords

Epigenomic preconditioning of peripheral monocytes determines their transcriptional response to the tumor microenvironment

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recommendations! Published in 2025 at "Genome Medicine"

DOI: 10.1186/s13073-025-01511-y

Abstract: Monocytes are recruited to tumors and undergo transcriptional reprogramming resulting in tumor-promoting functions. Epigenomic features, such as post-translational modification of histones and chromatin accessibility, are key determinants of transcription factor binding and thereby play an… read more here.

Keywords: peripheral monocytes; response tumor; preconditioning peripheral; tumor microenvironment ... See more keywords