Neurofilament light chain: a specific serum biomarker of axonal damage severity in rat models of Chemotherapy-Induced Peripheral Neurotoxicity
Sign Up to like & getrecommendations! Published in 2020 at "Archives of Toxicology"
DOI: 10.1007/s00204-020-02755-w
Abstract: Chemotherapy-Induced Peripheral Neurotoxicity (CIPN) is a severe and long-lasting side effect of anticancer therapy, which can severely impair patients’ quality of life. It is a sensory and length-dependent neuropathy, which predominantly affects large myelinated fibers.… read more here.
Keywords: axonal damage; severity; neurotoxicity; peripheral neurotoxicity ... See more keywords
Pharmacotherapy options for managing chemotherapy-induced peripheral neurotoxicity
Sign Up to like & getrecommendations! Published in 2018 at "Expert Opinion on Pharmacotherapy"
DOI: 10.1080/14656566.2017.1415326
Abstract: ABSTRACT Introduction: Prevention and treatment of chemotherapy-induced peripheral neurotoxicity (CIPN) are clinically-relevant unmet needs. Despite extensive efforts at the preclinical and clinical levels, no effective pharmacological interventions are available, and this unsatisfactory situation reflects a… read more here.
Keywords: chemotherapy; induced peripheral; peripheral neurotoxicity; chemotherapy induced ... See more keywords
Emerging pharmacological strategies for the management of chemotherapy-induced peripheral neurotoxicity (CIPN), based on novel CIPN mechanisms
Sign Up to like & getrecommendations! Published in 2020 at "Expert Review of Neurotherapeutics"
DOI: 10.1080/14737175.2020.1796639
Abstract: ABSTRACT Introduction Based on results of available clinical trials, the treatment and prevention of chemotherapy-induced peripheral neurotoxicity (CIPN) largely remains an unmet clinical need. However, new approaches have emerged in the last few years, attempting… read more here.
Keywords: neurotoxicity cipn; based novel; induced peripheral; peripheral neurotoxicity ... See more keywords
Optimal outcome measures for assessing exercise and rehabilitation approaches in chemotherapy-induced peripheral-neurotoxicity: Systematic review and consensus expert opinion
Sign Up to like & getrecommendations! Published in 2021 at "Expert Review of Neurotherapeutics"
DOI: 10.1080/14737175.2022.2018300
Abstract: ABSTRACT Introduction Chemotherapy-induced peripheral neurotoxicity (CIPN) remains a significant toxicity in cancer survivors without preventative strategies or rehabilitation. Exercise and physical activity-based interventions have demonstrated promise in reducing existing CIPN symptoms and potentially preventing toxicity,… read more here.
Keywords: outcome measures; rehabilitation; peripheral neurotoxicity; induced peripheral ... See more keywords
A randomized controlled study of a combination of internal and external treatments for albumin paclitaxel-related peripheral neurotoxicity: A randomized controlled: A study protocol
Sign Up to like & getrecommendations! Published in 2022 at "Medicine"
DOI: 10.1097/md.0000000000032252
Abstract: Introduction: Albumin-bound paclitaxel (nab-PTX), a novel paclitaxel preparation, has been found to successfully blocks tumor progression in breast and lung cancer. However, at the same time of as clinical application, neurotoxicity caused by nab-PTX has… read more here.
Keywords: randomized controlled; peripheral neurotoxicity; controlled study; neurotoxicity ... See more keywords
Chemotherapy‐induced peripheral neurotoxicity: A multifaceted, still unsolved issue
Sign Up to like & getrecommendations! Published in 2019 at "Journal of the Peripheral Nervous System"
DOI: 10.1111/jns.12337
Abstract: Chemotherapy‐induced peripheral neurotoxicity (CIPN) is a potentially dose‐limiting side effect of several commonly used cytotoxic chemotherapy agents. The main pharmacological classes that may cause CIPN include classical anticancer drugs, as well as the recently introduced… read more here.
Keywords: chemotherapy; induced peripheral; peripheral neurotoxicity; chemotherapy induced ... See more keywords
Calmangafodipir Reduces Sensory Alterations and Prevents Intraepidermal Nerve Fibers Loss in a Mouse Model of Oxaliplatin Induced Peripheral Neurotoxicity
Sign Up to like & getrecommendations! Published in 2020 at "Antioxidants"
DOI: 10.3390/antiox9070594
Abstract: Oxaliplatin (OHP) is an antineoplastic compound able to induce peripheral neurotoxicity. Oxidative stress has been suggested to be a key factor in the development of OHP-related peripheral neurotoxicity. Mangafodipir, a contrast agent possessing mitochondrial superoxide… read more here.
Keywords: calmangafodipir; intraepidermal nerve; induced peripheral; peripheral neurotoxicity ... See more keywords