JAK1 signaling in dendritic cells promotes peripheral tolerance in autoimmunity through PD-L1-mediated regulatory T cell induction.
Sign Up to like & getrecommendations! Published in 2022 at "Cell reports"
DOI: 10.1016/j.celrep.2022.110420
Abstract: Dendritic cells (DCs) induce peripheral T cell tolerance, but cell-intrinsic signaling cascades governing their stable tolerogenesis remain poorly defined. Janus Kinase 1 (JAK1) transduces cytokine-receptor signaling, and JAK inhibitors (Jakinibs), including JAK1-specific filgotinib, break inflammatory cycles… read more here.
Keywords: promotes peripheral; peripheral tolerance; cell; jak1 ... See more keywords
The historical postulate: Is it the basis, at the level of the system, for self‐nonself discrimination?
Sign Up to like & getrecommendations! Published in 2021 at "Scandinavian Journal of Immunology"
DOI: 10.1111/sji.13033
Abstract: Burnet envisaged the early presence of self‐antigens in development, or ‘the history’ of an animal, ablates the animal's ability to immunologically respond against them. Lederberg added the idea that the continuous presence of self‐antigens is… read more here.
Keywords: system; peripheral tolerance; historical postulate; activation ... See more keywords
Presentation of Autoantigen in Peripheral Lymph Nodes Is Sufficient for Priming Autoreactive CD8+ T Cells
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DOI: 10.3389/fimmu.2017.00113
Abstract: Peripheral tolerance is an important mechanism by which the immune system can guarantee a second line of defense against autoreactive T and B cells. One autoimmune disease that is related to a break of peripheral… read more here.
Keywords: cd8; lymph nodes; peripheral tolerance; cd8 cells ... See more keywords
Induction of Peripheral Tolerance in Ongoing Autoimmune Inflammation Requires Interleukin 27 Signaling in Dendritic Cells
Sign Up to like & getrecommendations! Published in 2017 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2017.01392
Abstract: Peripheral tolerance to autoantigens is induced via suppression of self-reactive lymphocytes, stimulation of tolerogenic dendritic cells (DCs) and regulatory T (Treg) cells. Interleukin (IL)-27 induces tolerogenic DCs and Treg cells; however, it is not known… read more here.
Keywords: induction peripheral; peripheral tolerance; tolerance; dendritic cells ... See more keywords