Peripheral viral challenge triggers hippocampal production of inflammatory proteins
Sign Up to like & getrecommendations! Published in 2017 at "Metabolic Brain Disease"
DOI: 10.1007/s11011-017-0030-4
Abstract: Peripheral viral infections increase seizure propensity and intensity in susceptible individuals. We have modeled this comorbidity by demonstrating that intraperitoneal (ip) injection of the conventional viral mimetic, polyinosinic-polycytidylic acid (PIC), renders the brain hypersusceptible to… read more here.
Keywords: challenge; pic challenge; increase; peripheral viral ... See more keywords
Peripheral viral challenge increases c-fos level in cerebral neurons.
Sign Up to like & getrecommendations! Published in 2021 at "Metabolic brain disease"
DOI: 10.1007/s11011-021-00819-z
Abstract: Peripheral viral infection can substantially alter brain function. We have previously shown that intraperitoneal (i.p.) injection of a viral mimetic, polyinosinic-polycytidylic acid (PIC), engenders hyperexcitability of cerebral neurons. Because neuronal activity is invariably associated with… read more here.
Keywords: cerebral neurons; challenge; fos; pic challenge ... See more keywords