Peripherally Acting &mgr;-Opioid Receptor Agonists Attenuate Ongoing Pain-associated Behavior and Spontaneous Neuronal Activity after Nerve Injury in Rats
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DOI: 10.1097/aln.0000000000002191
Abstract: Background: Ongoing neuropathic pain is difficult to treat. The authors examined whether dermorphin [D-Arg2, Lys4] (1–4) amide, a peripherally acting µ-opioid receptor agonist, attenuates ongoing pain-associated manifestations after nerve injury in rats and mice. Methods:… read more here.
Keywords: lys4 amide; peripherally acting; arg2 lys4; dermorphin arg2 ... See more keywords
Peripherally Acting μ-Opioid Receptor Antagonists for the Treatment of Opioid-Related Side Effects: Mechanism of Action and Clinical Implications
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DOI: 10.1177/0897190017732263
Abstract: Opioid receptors are distributed throughout the central and peripheral nervous systems and on many nonneuronal cells. Therefore, opioid administration induces effects beyond analgesia. In the enteric nervous system (ENS), stimulation of µ-opioid receptors triggers several… read more here.
Keywords: opioid receptor; peripherally acting; opioid related; receptor antagonists ... See more keywords
Mechanistic Characterization of the Pharmacological Profile of HS-731, a Peripherally Acting Opioid Analgesic, at the µ-, δ-, κ-Opioid and Nociceptin Receptors
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DOI: 10.3390/molecules27030919
Abstract: Accumulated preclinical and clinical data show that peripheral restricted opioids provide pain relief with reduced side effects. The peripherally acting opioid analgesic HS-731 is a potent dual μ-/δ-opioid receptor (MOR/DOR) full agonist, and a weak,… read more here.
Keywords: acting opioid; opioid analgesic; opioid receptors; peripherally acting ... See more keywords