Toxoplasma infection induces microglia-neuron contact and the loss of perisomatic inhibitory synapses.
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DOI: 10.1002/glia.23816
Abstract: Infection and inflammation within the brain induces changes in neuronal connectivity and function. The intracellular protozoan parasite, Toxoplasma gondii, is one pathogen that infects the brain and can cause encephalitis and seizures. Persistent infection by… read more here.
Keywords: infection; inhibitory synapses; perisomatic inhibitory; inhibitory ... See more keywords
Selective Extracellular Stimulation of Pharmacologically Distinct CCK/CB1R Positive Interneuron to Pyramidal Cell Perisomatic Inhibitory Synapses
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DOI: 10.1007/s12668-016-0310-1
Abstract: During prolonged whole cell recording, the intracellular contents are progressively dialyzed with the pipette solution; this often leads to significant changes in synaptic efficacy. To overcome this problem, we developed an approach allowing reliable extracellular… read more here.
Keywords: pyramidal; extracellular stimulation; stimulation; inhibitory synapses ... See more keywords
Reorganization of Parvalbumin Immunopositive Perisomatic Innervation of Principal Cells in Focal Cortical Dysplasia Type IIB in Human Epileptic Patients
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DOI: 10.3390/ijms23094746
Abstract: Focal cortical dysplasia (FCD) is one of the most common causes of drug-resistant epilepsy. As several studies have revealed, the abnormal functioning of the perisomatic inhibitory system may play a role in the onset of… read more here.
Keywords: principal cells; cortical dysplasia; type iib; perisomatic inhibitory ... See more keywords