Strategies for preventing peritoneal fibrosis in peritoneal dialysis patients: new insights based on peritoneal inflammation and angiogenesis
Sign Up to like & getrecommendations! Published in 2017 at "Frontiers of Medicine"
DOI: 10.1007/s11684-017-0571-2
Abstract: Peritoneal dialysis (PD) is an established form of renal replacement therapy. Long-term PD leads to morphologic and functional changes to the peritoneal membrane (PM), which is defined as peritoneal fibrosis, a known cause of loss… read more here.
Keywords: peritoneal fibrosis; peritoneal inflammation; inflammation angiogenesis;
Proteomic Characterization of Peritoneal Extracellular Vesicles in a Mouse Model of Peritoneal Fibrosis.
Sign Up to like & getrecommendations! Published in 2023 at "Journal of proteome research"
DOI: 10.1021/acs.jproteome.2c00713
Abstract: Peritoneal fibrosis progression is regarded as a significant cause of the loss of peritoneal function, markedly limiting the application of peritoneal dialysis (PD). However, the pathogenesis of peritoneal fibrosis remains to be elucidated. Tissue-derived extracellular… read more here.
Keywords: proteomic characterization; peritoneal fibrosis; extracellular vesicles; characterization peritoneal ... See more keywords
A high-density collagen xerogel thread prevents the progression of peritoneal fibrosis.
Sign Up to like & getrecommendations! Published in 2018 at "Biomaterials science"
DOI: 10.1039/c8bm00536b
Abstract: Peritoneal fibrosis is often provoked by peritoneal dialysis and is an essential precursor condition to the development of encapsulating peritoneal sclerosis. This study aimed to determine the efficacy of a high-density collagen xerogel thread (CXT)… read more here.
Keywords: peritoneal fibrosis; density collagen; fibrosis; high density ... See more keywords
Inhibition of EZH2 mitigates peritoneal fibrosis and lipid precipitation in peritoneal mesothelial cells mediated by klotho
Sign Up to like & getrecommendations! Published in 2023 at "Renal Failure"
DOI: 10.1080/0886022x.2022.2149411
Abstract: Abstract Background Peritoneal fibrosis caused by long-term peritoneal dialysis (PD) is the main reason why patients withdraw from PD treatment. Lipid accumulation in the peritoneum was shown to participate in fibrosis, and klotho is a… read more here.
Keywords: gsk343; peritoneal fibrosis; effect; ezh2 ... See more keywords
SO006DIPEPTIDYL PEPTIDASE-4 INHIBITOR PROTECTS FROM PERITONEAL FIBROSIS--- A TRANSLATIONAL RESEARCH FROM CLINICAL OBSERVATION TO ANIMAL STUDY
Sign Up to like & getrecommendations! Published in 2020 at "Nephrology Dialysis Transplantation"
DOI: 10.1093/ndt/gfaa139.so006
Abstract: The increasing prevalence rate of end-stage renal disease (ESRD) has emerged as a global health burden. Peritoneal dialysis (PD) possesses the survival and convenient advantage for ESRD during the first 2 years of dialysis treatment.… read more here.
Keywords: peritoneal fibrosis; esrd; diabetic esrd; esrd patients ... See more keywords
P1196AN INIHIBITOR OF KRUPPEL-LIKE FACTOR 5 SUPPRESSES PERITONEAL FIBROSIS IN MICE
Sign Up to like & getrecommendations! Published in 2020 at "Nephrology Dialysis Transplantation"
DOI: 10.1093/ndt/gfaa142.p1196
Abstract: We presented previously that Am80, a synthetic retinoic acid receptor α specific agonist, inhibited the expression of Krüppel-like transcription factor 5 (KLF5) and reduced peritoneal fibrosis in mice. Now, we examined further detail about the… read more here.
Keywords: peritoneal fibrosis; fibrosis; fibrosis mice; klf5 ... See more keywords
Newly designed Protein Transduction Domain (PTD)‐mediated BMP‐7 is a potential therapeutic for peritoneal fibrosis
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Cellular and Molecular Medicine"
DOI: 10.1111/jcmm.15992
Abstract: While the bone morphogenetic protein‐7 (BMP‐7) is a well‐known therapeutic growth factor reverting many fibrotic diseases, including peritoneal fibrosis by peritoneal dialysis (PD), soluble growth factors are largely limited in clinical applications owing to their… read more here.
Keywords: peritoneal fibrosis; bmp; protein transduction; ptd ... See more keywords
Nintedanib attenuates peritoneal fibrosis by inhibiting mesothelial‐to‐mesenchymal transition, inflammation and angiogenesis
Sign Up to like & getrecommendations! Published in 2021 at "Journal of Cellular and Molecular Medicine"
DOI: 10.1111/jcmm.16518
Abstract: Nintedanib, an Food and Drug Administration (FDA) approved multiple tyrosine kinase inhibitor, exhibits an anti‐fibrotic effect in lung and kidneys. Its effect on peritoneal fibrosis remains unexplored. In this study, we found that nintedanib administration… read more here.
Keywords: peritoneal fibrosis; fibrosis; nintedanib; growth factor ... See more keywords
Effluent decoy receptor 2 as a novel biomarker of peritoneal fibrosis in peritoneal dialysis patients
Sign Up to like & getrecommendations! Published in 2022 at "Peritoneal Dialysis International"
DOI: 10.1177/08968608211067866
Abstract: Background: Peritoneal fibrosis (PF) is a common complication of peritoneal dialysis (PD), but a specific and sensitive biomarker for PF is lacking. The present study aimed to determine the use of effluent decoy receptor 2… read more here.
Keywords: peritoneal fibrosis; biomarker; peritoneal dialysis; decoy receptor ... See more keywords
Delayed administration of suramin attenuates peritoneal fibrosis in rats
Sign Up to like & getrecommendations! Published in 2019 at "BMC Nephrology"
DOI: 10.1186/s12882-019-1597-2
Abstract: BackgroundPeritoneal fibrosis is the most common complication of peritoneal dialysis, but there is currently no effective treatment. We previously reported that suramin pretreatment prevents the development of peritoneal fibrosis in a rat model of peritoneal… read more here.
Keywords: peritoneal fibrosis; administration suramin; fibrosis; delayed administration ... See more keywords
Hyperspectral evaluation of peritoneal fibrosis in mouse models.
Sign Up to like & getrecommendations! Published in 2020 at "Biomedical optics express"
DOI: 10.1364/boe.387837
Abstract: Analysis of morphological changes of the peritoneal membrane is an essential part of animal studies when investigating molecular mechanisms involved in the development of peritoneal fibrosis or testing the effects of potential therapeutic agents. Current… read more here.
Keywords: peritoneal fibrosis; hyperspectral evaluation; evaluation peritoneal; fibrosis ... See more keywords