miR‐15a‐5p suppresses inflammation and fibrosis of peritoneal mesothelial cells induced by peritoneal dialysis via targeting VEGFA
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Cellular Physiology"
DOI: 10.1002/jcp.27660
Abstract: Long‐term peritoneal dialysis (PD) often ends up with ultrafiltration failure (UFF) which is partially caused by persistent inflammation and fibrosis of peritoneal tissues. However, the mechanism is still unclear. In the current study, the peritoneum… read more here.
Keywords: inflammation fibrosis; fibrosis peritoneal; mir 15a; mesothelial cells ... See more keywords
Role of IGF-1R in epithelial–mesenchymal transdifferentiation of human peritoneal mesothelial cells
Sign Up to like & getrecommendations! Published in 2022 at "Clinical and Experimental Nephrology"
DOI: 10.1007/s10157-022-02209-w
Abstract: Peritoneal fibrosis (PF) is caused by epithelial-mesenchymal transdifferentiation (EMT) in the peritoneum under high glucose (HG) conditions. The study aimed to explored the role of Insulin-like growth factor 1 receptor (IGF-1R) in the regulation of… read more here.
Keywords: mesenchymal transdifferentiation; human peritoneal; peritoneal mesothelial; mesothelial cells ... See more keywords
AGEs induce epithelial to mesenchymal transformation of human peritoneal mesothelial cells via upregulation of STAT3
Sign Up to like & getrecommendations! Published in 2019 at "Glycoconjugate Journal"
DOI: 10.1007/s10719-019-09861-7
Abstract: Epithelial-mesenchymal transition (EMT) in peritoneum was induced during peritoneal dialysis (PD), which finally caused progressive fibrosis. However, the underlying mechanisms were not well elucidated. We established advanced glycation end-products (AGEs)-induced EMT model using primary human… read more here.
Keywords: human peritoneal; ages induce; stat3; mesothelial cells ... See more keywords
LCZ696, an angiotensin receptor-neprilysin inhibitor, ameliorates epithelial-mesenchymal transition of peritoneal mesothelial cells and M2 macrophage polarization
Sign Up to like & getrecommendations! Published in 2024 at "Renal Failure"
DOI: 10.1080/0886022x.2024.2392849
Abstract: Abstract Aims To investigate the effects and mechanisms of LCZ696, an angiotensin receptor-neprilysin inhibitor (ARNI), on epithelial-mesenchymal transition (EMT) of peritoneal mesothelial cells and on macrophage M2 polarization. Methods We examined the effects of LCZ696… read more here.
Keywords: mesothelial cells; lcz696 angiotensin; macrophage polarization; peritoneal mesothelial ... See more keywords
MMP‐7 affects peritoneal ultrafiltration associated with elevated aquaporin‐1 expression via MAPK/ERK pathway in peritoneal mesothelial cells
Sign Up to like & getrecommendations! Published in 2021 at "Journal of Cellular and Molecular Medicine"
DOI: 10.1111/jcmm.16697
Abstract: Peritoneal membrane dysfunction and the resulting ultrafiltration failure are the major disadvantages of long‐term peritoneal dialysis (PD). It becomes increasingly clear that mesothelial cells play a vital role in the pathophysiological changes of the peritoneal… read more here.
Keywords: peritoneal ultrafiltration; mmp; mesothelial cells; peritoneal mesothelial ... See more keywords
Mammalian Target of Rapamycin Complex 1 Activation Disrupts the Low-Density Lipoprotein Receptor Pathway: A Novel Mechanism for Extracellular Matrix Accumulation in Human Peritoneal Mesothelial Cells
Sign Up to like & getrecommendations! Published in 2018 at "American Journal of Nephrology"
DOI: 10.1159/000494144
Abstract: Peritoneal fibrosis (PF) is characterized by progressive extracellular matrix (ECM) accumulation. Increasing evidence has suggested that ECM synthesis was increased in human peritoneal mesothelial cells (HPMCs) under high-glucose conditions, but the effects of high-glucose peritoneal… read more here.
Keywords: human peritoneal; accumulation; pds; extracellular matrix ... See more keywords
Long-term peritoneal dialysate exposure modulates expression of membrane complement regulators in human peritoneal mesothelial cells
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Medicine"
DOI: 10.3389/fmed.2022.972592
Abstract: The membrane complement regulators (CRegs) CD46, CD55, and CD59 are highly expressed on human peritoneal mesothelial cells. However, how mesothelial CRegs change according to the peritoneal dialysis (PD) history of patients has remained unclear. We… read more here.
Keywords: pdf; peritoneal mesothelial; mesothelial cells; membrane complement ... See more keywords
Polyphenols Attenuate Highly-Glycosylated Haemoglobin-Induced Damage in Human Peritoneal Mesothelial Cells
Sign Up to like & getrecommendations! Published in 2020 at "Antioxidants"
DOI: 10.3390/antiox9070572
Abstract: We investigated the cytoprotective role of the dietary polyphenols on putative damage induced by Amadori adducts in Human Peritoneal Mesothelial Cells (HPMCs). Increased accumulation of early products of non-enzymatic protein glycation—Amadori adducts—in the peritoneal dialysis… read more here.
Keywords: human peritoneal; amadori adducts; mesothelial cells; peritoneal dialysis ... See more keywords
Mechanisms of Peritoneal Mesothelial Cells in Peritoneal Adhesion
Sign Up to like & getrecommendations! Published in 2022 at "Biomolecules"
DOI: 10.3390/biom12101498
Abstract: A peritoneal adhesion (PA) is a fibrotic tissue connecting the abdominal or visceral organs to the peritoneum. The formation of PAs can induce a variety of clinical diseases. However, there is currently no effective strategy… read more here.
Keywords: pas; peritoneal mesothelial; mesothelial cells; peritoneal adhesion ... See more keywords