Sphingosine 1-phosphate signaling in perivascular cells enhances inflammation and fibrosis in the kidney
Sign Up to like & getrecommendations! Published in 2022 at "Science Translational Medicine"
DOI: 10.1126/scitranslmed.abj2681
Abstract: Chronic kidney disease (CKD), characterized by sustained inflammation and progressive fibrosis, is highly prevalent and can eventually progress to end-stage kidney disease. However, current treatments to slow CKD progression are limited. Sphingosine 1-phosphate (S1P), a… read more here.
Keywords: s1p; perivascular cells; kidney; kidney disease ... See more keywords
Oxidative Stress Product, 4-Hydroxy-2-Nonenal, Induces the Release of Tissue Factor-Positive Microvesicles From Perivascular Cells Into Circulation
Sign Up to like & getrecommendations! Published in 2020 at "Arteriosclerosis, Thrombosis, and Vascular Biology"
DOI: 10.1161/atvbaha.120.315187
Abstract: Supplemental Digital Content is available in the text. Objective: TF (Tissue factor) plays a key role in hemostasis, but an aberrant expression of TF leads to thrombosis. The objective of the present study is to… read more here.
Keywords: hydroxy nonenal; hne; circulation; perivascular cells ... See more keywords
Breast pericytes: a newly identified driver of tumor cell proliferation
Sign Up to like & getrecommendations! Published in 2024 at "Frontiers in Oncology"
DOI: 10.3389/fonc.2024.1455484
Abstract: Introduction Effective treatment of breast cancer remains a formidable challenge, partly due to our limited understanding of the complex microenvironmental factors that contribute to disease pathology. Among these factors are tissue-resident perivascular cells, which play… read more here.
Keywords: breast; biology; cell; tumor ... See more keywords