20(S)‐protopanaxadiol induces apoptosis in human umbilical vein endothelial cells by activating the PERK‐eIF2alpha‐ATF4 signaling pathway
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Cellular Biochemistry"
DOI: 10.1002/jcb.27785
Abstract: 20(S)‐protopanaxadiol (PPD)‐type ginsenosides are generally believed to be the most pharmacologically active components of Panax ginseng. These compounds induce apoptotic cell death in various cancer cells, which suggests that they have anti‐cancer activity. Anti‐angiogenesis is… read more here.
Keywords: ppd; human umbilical; perk; expression ... See more keywords
Activation of PERK in ET‐1‐ and thrombin‐induced pulmonary fibroblast differentiation: Inhibitory effects of curcumin
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Cellular Physiology"
DOI: 10.1002/jcp.28256
Abstract: In the present study, we investigated the role of PKR‐like endoplasmic reticular kinase (PERK), an endoplasmic reticulum (ER) stress kinase, in endothelin 1 (ET‐1)‐ and thrombin‐induced pulmonary fibrosis (PF), and the preventive effects of curcumin… read more here.
Keywords: kinase; perk; differentiation; col ... See more keywords
ER stress protein PERK promotes inappropriate innate immune responses and pathogenesis during RSV infection
Sign Up to like & getrecommendations! Published in 2021 at "Journal of Leukocyte Biology"
DOI: 10.1002/jlb.3a0520-322rr
Abstract: The activation of dendritic cells (DC) during respiratory viral infections is central to directing the immune response and the pathologic outcome. In these studies, the effect of RSV infection on development of ER stress responses… read more here.
Keywords: perk; innate; rsv infection; infection ... See more keywords
β-Asarone Regulates ER Stress and Autophagy Via Inhibition of the PERK/CHOP/Bcl-2/Beclin-1 Pathway in 6-OHDA-Induced Parkinsonian Rats
Sign Up to like & getrecommendations! Published in 2019 at "Neurochemical Research"
DOI: 10.1007/s11064-019-02757-w
Abstract: Abstractβ-Asarone (1,2,4-trimethoxy-5-[(Z)-prop-1-enyl]benzene) is an essential component of Acorus tatarinowii Schott volatile oil. Previous research has observed that β-asarone effectively attenuated symptoms in parkinsonian rats and improved their performance, but the mechanism of this effect remains… read more here.
Keywords: induced parkinsonian; parkinsonian rats; stress autophagy; ohda induced ... See more keywords
Endoplasmic Reticulum Stress Regulates Cardiomyocyte Apoptosis in Myocardial Fibrosis Development via PERK-Mediated Autophagy
Sign Up to like & getrecommendations! Published in 2020 at "Cardiovascular Toxicology"
DOI: 10.1007/s12012-020-09586-2
Abstract: Endoplasmic reticulum stress (ERS) is involved in a variety of diseases. Recently, it was found that ERS induces not only apoptosis but also autophagy. Previous studies showed that inhibition of autophagy alleviates cell injury. The… read more here.
Keywords: endoplasmic reticulum; apoptosis; reticulum stress; perk ... See more keywords
Polystyrene microplastics-triggered mitophagy and oxidative burst via activation of PERK pathway
Sign Up to like & getrecommendations! Published in 2021 at "Science of The Total Environment"
DOI: 10.1016/j.scitotenv.2021.146753
Abstract: Abstract Worldwide annual production of plastics is estimated to be > 300 Million Tons. Plastic debris in aquatic environment can degrade into micro/nanoplastics, leading to biopersistence, bioaccumulation, and toxicity. Here, we determined the potential hepatotoxicity… read more here.
Keywords: activation; perk; polystyrene microplastics; mitophagy oxidative ... See more keywords
Endoplasmic Reticulum Stress-Activated PERK-eIF2α-ATF4 Signaling Pathway is Involved in the Ameliorative Effects of Ginseng Polysaccharides against Cisplatin-Induced Nephrotoxicity in Mice
Sign Up to like & getrecommendations! Published in 2021 at "ACS Omega"
DOI: 10.1021/acsomega.0c06339
Abstract: Although previous studies have reported that saponins (ginsenosides, the major active and most representative ingredients in Panax ginseng C.A. Meyer) exerted a good ameliorative effect on cisplatin (CP)-induced acute kidney injury in animal models, little… read more here.
Keywords: eif2 atf4; perk eif2; stress; perk ... See more keywords
Cell-type-specific disruption of PERK-eIF2α signaling in dopaminergic neurons alters motor and cognitive function
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DOI: 10.1038/s41380-021-01099-w
Abstract: Endoplasmic reticulum (ER) stress and the unfolded protein response (UPR) has been shown to activate the eIF2α kinase PERK to directly regulate translation initiation. Tight control of PERK-eIF2α signaling has been shown to be necessary… read more here.
Keywords: cognitive function; perk; perk eif2; eif2 signaling ... See more keywords
Quercetin Protects Hepatocyte from Ferroptosis by Depressing Mitochondria-reticulum Interaction Through PERK Downregulation in Alcoholic Liver (P06-056-19).
Sign Up to like & getrecommendations! Published in 2019 at "Current developments in nutrition"
DOI: 10.1093/cdn/nzz031.p06-056-19
Abstract: Objectives Considering the disorder of lipid metabolism and iron deposition in alcoholic liver (ALD), ferroptosis may play a vital role in its pathogenesis. In the present research, we sought to determine whether ferroptosis occurred in… read more here.
Keywords: perk; alcoholic liver; increased mams; ferroptosis ... See more keywords
PERK/eIF2α signaling inhibits HIF-induced gene expression during the unfolded protein response via YB1-dependent regulation of HIF1α translation
Sign Up to like & getrecommendations! Published in 2018 at "Nucleic Acids Research"
DOI: 10.1093/nar/gky127
Abstract: Abstract HIF1α (hypoxia inducible factor 1α) is the central regulator of the cellular response to low oxygen and its activity is deregulated in multiple human pathologies. Consequently, given the importance of HIF signaling in disease,… read more here.
Keywords: hif1 translation; response; unfolded protein; protein response ... See more keywords
Increased HMGB1 expression correlates with higher expression of c-IAP2 and pERK in colorectal cancer
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DOI: 10.1097/md.0000000000014069
Abstract: Abstract The aim of this study was to investigate the relationship between high-mobility group box 1 (HMGB1) and colorectal cancer (CRC). In this prospective study, patients with CRC undergoing primary surgery and healthy subjects (control… read more here.
Keywords: expression; perk; iap2; hmgb1 ... See more keywords