Endoplasmic Reticulum Stress Exacerbates Nucleus Pulposus Cell Pyroptosis via PERK-Dependent Activation of JAK1-STAT3 Signaling.
Sign Up to like & getrecommendations! Published in 2025 at "Cell biochemistry and function"
DOI: 10.1002/cbf.70148
Abstract: Endoplasmic reticulum stress (ERS) has been implicated in the pathophysiology of intervertebral disc degeneration (IDD), yet the precise molecular mechanisms linking excessive ERS to pyroptotic cell death in nucleus pulposus cells (NPCs) remain elusive. This… read more here.
Keywords: activation; perk; jak1 stat3; pyroptosis ... See more keywords
Oligodendrocyte‐selective deletion of the eIF2α kinase Perk/Eif2ak3 limits functional recovery after spinal cord injury
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DOI: 10.1002/glia.24525
Abstract: After spinal cord injury (SCI), re‐establishing cellular homeostasis is critical to optimize functional recovery. Central to that response is PERK signaling, which ultimately initiates a pro‐apoptotic response if cellular homeostasis cannot be restored. Oligodendrocyte (OL)… read more here.
Keywords: spinal cord; recovery; injury; perk ... See more keywords
20(S)‐protopanaxadiol induces apoptosis in human umbilical vein endothelial cells by activating the PERK‐eIF2alpha‐ATF4 signaling pathway
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Cellular Biochemistry"
DOI: 10.1002/jcb.27785
Abstract: 20(S)‐protopanaxadiol (PPD)‐type ginsenosides are generally believed to be the most pharmacologically active components of Panax ginseng. These compounds induce apoptotic cell death in various cancer cells, which suggests that they have anti‐cancer activity. Anti‐angiogenesis is… read more here.
Keywords: ppd; human umbilical; perk; expression ... See more keywords
Activation of PERK in ET‐1‐ and thrombin‐induced pulmonary fibroblast differentiation: Inhibitory effects of curcumin
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Cellular Physiology"
DOI: 10.1002/jcp.28256
Abstract: In the present study, we investigated the role of PKR‐like endoplasmic reticular kinase (PERK), an endoplasmic reticulum (ER) stress kinase, in endothelin 1 (ET‐1)‐ and thrombin‐induced pulmonary fibrosis (PF), and the preventive effects of curcumin… read more here.
Keywords: kinase; perk; differentiation; col ... See more keywords
ER stress protein PERK promotes inappropriate innate immune responses and pathogenesis during RSV infection
Sign Up to like & getrecommendations! Published in 2021 at "Journal of Leukocyte Biology"
DOI: 10.1002/jlb.3a0520-322rr
Abstract: The activation of dendritic cells (DC) during respiratory viral infections is central to directing the immune response and the pathologic outcome. In these studies, the effect of RSV infection on development of ER stress responses… read more here.
Keywords: perk; innate; rsv infection; infection ... See more keywords
Mild endoplasmic reticulum stress alleviates FB1-triggered intestinal pyroptosis via the Sec62-PERK pathway
Sign Up to like & getrecommendations! Published in 2024 at "Cell Biology and Toxicology"
DOI: 10.1007/s10565-024-09868-3
Abstract: Fumonisin B1 (FB1), a water-soluble mycotoxin released by Fusarium moniliforme Sheld, is widely present in corn and its derivative products, and seriously endangers human life and health. Recent studies have reported that FB1 can lead… read more here.
Keywords: sec62; pyroptosis; perk pathway; fb1 ... See more keywords
β-Asarone Regulates ER Stress and Autophagy Via Inhibition of the PERK/CHOP/Bcl-2/Beclin-1 Pathway in 6-OHDA-Induced Parkinsonian Rats
Sign Up to like & getrecommendations! Published in 2019 at "Neurochemical Research"
DOI: 10.1007/s11064-019-02757-w
Abstract: Abstractβ-Asarone (1,2,4-trimethoxy-5-[(Z)-prop-1-enyl]benzene) is an essential component of Acorus tatarinowii Schott volatile oil. Previous research has observed that β-asarone effectively attenuated symptoms in parkinsonian rats and improved their performance, but the mechanism of this effect remains… read more here.
Keywords: induced parkinsonian; parkinsonian rats; stress autophagy; ohda induced ... See more keywords
Endoplasmic Reticulum Stress Regulates Cardiomyocyte Apoptosis in Myocardial Fibrosis Development via PERK-Mediated Autophagy
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DOI: 10.1007/s12012-020-09586-2
Abstract: Endoplasmic reticulum stress (ERS) is involved in a variety of diseases. Recently, it was found that ERS induces not only apoptosis but also autophagy. Previous studies showed that inhibition of autophagy alleviates cell injury. The… read more here.
Keywords: endoplasmic reticulum; apoptosis; reticulum stress; perk ... See more keywords
Polystyrene microplastics-triggered mitophagy and oxidative burst via activation of PERK pathway
Sign Up to like & getrecommendations! Published in 2021 at "Science of The Total Environment"
DOI: 10.1016/j.scitotenv.2021.146753
Abstract: Abstract Worldwide annual production of plastics is estimated to be > 300 Million Tons. Plastic debris in aquatic environment can degrade into micro/nanoplastics, leading to biopersistence, bioaccumulation, and toxicity. Here, we determined the potential hepatotoxicity… read more here.
Keywords: activation; perk; polystyrene microplastics; mitophagy oxidative ... See more keywords
Endoplasmic Reticulum Stress-Activated PERK-eIF2α-ATF4 Signaling Pathway is Involved in the Ameliorative Effects of Ginseng Polysaccharides against Cisplatin-Induced Nephrotoxicity in Mice
Sign Up to like & getrecommendations! Published in 2021 at "ACS Omega"
DOI: 10.1021/acsomega.0c06339
Abstract: Although previous studies have reported that saponins (ginsenosides, the major active and most representative ingredients in Panax ginseng C.A. Meyer) exerted a good ameliorative effect on cisplatin (CP)-induced acute kidney injury in animal models, little… read more here.
Keywords: eif2 atf4; perk eif2; stress; perk ... See more keywords
Activation of the PERK Branch of the UPR as a Strategy for Improving Outcomes in Acute Ischemic Stroke
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DOI: 10.1021/acsomega.5c00125
Abstract: Brain ischemia disrupts endoplasmic reticulum (ER) dynamics, causes ER stress, and triggers the unfolded protein response (UPR). During the UPR, protein kinase RNA-like ER kinase (PERK) phosphorylates eIF2α, shutting down global protein synthesis, inhibits protein… read more here.
Keywords: acute ischemic; ischemic stroke; stroke; strategy ... See more keywords