Oligodendrocyte-specific ATF4 inactivation does not influence the development of EAE
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Neuroinflammation"
DOI: 10.1186/s12974-019-1415-6
Abstract: BackgroundMultiple sclerosis (MS) and its animal model, experimental autoimmune encephalomyelitis (EAE), are inflammatory demyelinating and neurodegenerative diseases of the CNS. Although recent studies suggest the neuroprotective effects of oligodendrocytes in neurodegenerative diseases, it remains unknown… read more here.
Keywords: atf4 inactivation; eae; activation; specifically oligodendrocytes ... See more keywords
Dual leucine zipper kinase-dependent PERK activation contributes to neuronal degeneration following insult
Sign Up to like & getrecommendations! Published in 2017 at "eLife"
DOI: 10.7554/elife.20725
Abstract: The PKR-like endoplasmic reticulum kinase (PERK) arm of the Integrated Stress Response (ISR) is implicated in neurodegenerative disease, although the regulators and consequences of PERK activation following neuronal injury are poorly understood. Here we show… read more here.
Keywords: leucine zipper; kinase; dual leucine; perk ... See more keywords