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   Articles with "perk eif2" as a keyword



Tetrahydrocurcumin Attenuates Polymyxin B Sulfate‐Induced HK‐2 Cells Apoptosis by Inhibiting Endoplasmic Reticulum Stress‐Mediated PERK/eIF2α/ATF4/CHOP Signaling Pathway Axis

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recommendations! Published in 2024 at "Environmental Toxicology"

DOI: 10.1002/tox.24376

Abstract: The clinical application of polymyxin B (PMB) is limited by its nephrotoxic effects, making the reduction of PMB‐induced nephrotoxicity has become a pressing concern for clinicians. Tetrahydrocurcumin (THC), known for its beneficial characteristics in biological… read more here.

Keywords: induced nephrotoxicity; stress; eif2 atf4; pmb ... See more keywords

Curcumin Attenuates the PERK-eIF2α Signaling to Relieve Acrylamide-Induced Neurotoxicity in SH‑SY5Y Neuroblastoma Cells

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recommendations! Published in 2022 at "Neurochemical Research"

DOI: 10.1007/s11064-021-03504-w

Abstract: Curcumin is a natural polyphenolic compound with neuroprotective and antioxidant properties. Acrylamide (ACR) is a by-product of food processing that produces neurotoxicity in humans and animals. The pancreatic endoplasmic reticulum kinase (PERK)-eukaryotic initiation factor-2α (eIF2α)… read more here.

Keywords: eif2 signaling; sy5y; induced neurotoxicity; acr induced ... See more keywords

Hes1 Knockdown Exacerbates Ischemic Stroke Following tMCAO by Increasing ER Stress-Dependent Apoptosis via the PERK/eIF2α/ATF4/CHOP Signaling Pathway

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recommendations! Published in 2019 at "Neuroscience Bulletin"

DOI: 10.1007/s12264-019-00411-7

Abstract: Apoptosis induced by endoplasmic reticulum (ER) stress plays a crucial role in mediating brain damage after ischemic stroke. Recently, Hes1 (hairy and enhancer of split 1) has been implicated in the regulation of ER stress,… read more here.

Keywords: eif2 atf4; ischemic stroke; apoptosis; perk eif2 ... See more keywords

Pien Tze Huang ameliorates liver injury by inhibiting the PERK/eIF2α signaling pathway in alcohol and high-fat diet rats.

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recommendations! Published in 2018 at "Acta histochemica"

DOI: 10.1016/j.acthis.2018.06.006

Abstract: OBJECTIVE To explore whether Pien Tze Huang (PTH) exerts a hepatoprotective effect via inhibiting the PERK/eIF2ɑ signaling pathway using an experimental animal model of alcoholic and high-fat diet rats. METHODS A liver injury rat model… read more here.

Keywords: fat diet; perk eif2; high fat; diet rats ... See more keywords

The regulation of cellular apoptosis by the ROS‐triggered PERK/EIF2&agr;/chop pathway plays a vital role in bisphenol A‐induced male reproductive toxicity

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recommendations! Published in 2017 at "Toxicology and Applied Pharmacology"

DOI: 10.1016/j.taap.2016.11.013

Abstract: Abstract Bisphenol A (2,2‐bis(4‐hydroxyphenyl)propane, BPA) is ubiquitous in the environment, wildlife, and humans. Evidence from past studies suggests that BPA is associated with decreased semen quality. However, the molecular basis for the adverse effect of… read more here.

Keywords: bpa; perk eif2; agr chop; eif2 agr ... See more keywords
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Endoplasmic Reticulum Stress-Activated PERK-eIF2α-ATF4 Signaling Pathway is Involved in the Ameliorative Effects of Ginseng Polysaccharides against Cisplatin-Induced Nephrotoxicity in Mice

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recommendations! Published in 2021 at "ACS Omega"

DOI: 10.1021/acsomega.0c06339

Abstract: Although previous studies have reported that saponins (ginsenosides, the major active and most representative ingredients in Panax ginseng C.A. Meyer) exerted a good ameliorative effect on cisplatin (CP)-induced acute kidney injury in animal models, little… read more here.

Keywords: eif2 atf4; perk eif2; stress; perk ... See more keywords

Cell-type-specific disruption of PERK-eIF2α signaling in dopaminergic neurons alters motor and cognitive function

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recommendations! Published in 2021 at "Molecular Psychiatry"

DOI: 10.1038/s41380-021-01099-w

Abstract: Endoplasmic reticulum (ER) stress and the unfolded protein response (UPR) has been shown to activate the eIF2α kinase PERK to directly regulate translation initiation. Tight control of PERK-eIF2α signaling has been shown to be necessary… read more here.

Keywords: cognitive function; perk; perk eif2; eif2 signaling ... See more keywords
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Hypoxia Induces Growth Differentiation Factor 15 to Promote the Metastasis of Colorectal Cancer via PERK-eIF2α Signaling

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recommendations! Published in 2020 at "BioMed Research International"

DOI: 10.1155/2020/5958272

Abstract: Hypoxia plays an essential role in orchestrating Epithelial-mesenchymal transition and promoting metastasis of colorectal cancer. However, the underlying mechanisms are still not well elucidated. Here, we present that hypoxic exposure causes endoplasmic reticulum stress and… read more here.

Keywords: metastasis colorectal; colorectal cancer; perk eif2; eif2 signaling ... See more keywords
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Salubrinal Regulates the Apoptosis of Adrenocortical Carcinoma Cells via the PERK/eIF2α/ATF4 Signaling Pathway

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recommendations! Published in 2021 at "International Journal of Endocrinology"

DOI: 10.1155/2021/5038130

Abstract: The protein-kinase-R- (PKR-) like endoplasmic reticulum kinase (PERK) signaling pathway is a well-known promoter of cell apoptosis. In this study, we aimed to determine whether salubrinal (Sal), a selective activator of eukaryotic translation initiation factor… read more here.

Keywords: eif2 atf4; eif2; atf4 signaling; perk eif2 ... See more keywords

GluN2B-containing NMDA receptor attenuated neuronal apoptosis in the mouse model of HIBD through inhibiting endoplasmic reticulum stress-activated PERK/eIF2α signaling pathway

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recommendations! Published in 2024 at "Frontiers in Molecular Neuroscience"

DOI: 10.3389/fnmol.2024.1375843

Abstract: Introduction Neonatal hypoxic-ischemic brain damage (HIBD) refers to brain damage in newborns caused by hypoxia and reduced or even stopped cerebral blood flow during the perinatal period. Currently, there are no targeted treatments for neonatal… read more here.

Keywords: hibd; perk eif2; neuronal apoptosis; brain damage ... See more keywords

Didang Tang alleviates neuronal ferroptosis after intracerebral hemorrhage by modulating the PERK/eIF2α/ATF4/CHOP/GPX4 signaling pathway

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recommendations! Published in 2024 at "Frontiers in Pharmacology"

DOI: 10.3389/fphar.2024.1472813

Abstract: Introduction Ferroptosis is a crucial process contributing to neuronal damage following intracerebral hemorrhage (ICH). Didang Tang (DDT), a traditional therapeutic, has been used clinically to manage ICH for many years, yet the molecular mechanisms by… read more here.

Keywords: eif2 atf4; ddt; ferroptosis; perk eif2 ... See more keywords