Osteopontin Augments M2 Microglia Response and Separates M1- and M2-Polarized Microglial Activation in Permanent Focal Cerebral Ischemia
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DOI: 10.1155/2017/7189421
Abstract: Background Focal cerebral ischemia induces distinct neuroinflammatory processes. We recently reported the extracellular phosphor-glyco-protein osteopontin (OPN) to directly affect primary microglia in vitro, promoting survival while shifting their inflammatory profile towards a more neutral phenotype.… read more here.
Keywords: permanent focal; cerebral ischemia; focal cerebral; ischemia ... See more keywords