Membrane Permeability in Cyclic Peptides is Modulated by Core Conformations
Sign Up to like & getrecommendations! Published in 2021 at "Journal of chemical information and modeling"
DOI: 10.1021/acs.jcim.0c00803
Abstract: Cyclic peptides have the potential to bind to challenging targets, which are undruggable with small molecules, but their application is limited by low membrane permeability. Here, using a series of cyclic pentapeptides, we showed that… read more here.
Keywords: permeability cyclic; membrane permeability; permeability; peptides modulated ... See more keywords
Improvement on Permeability of Cyclic Peptide/Peptidomimetic: Backbone N-Methylation as A Useful Tool
Sign Up to like & getrecommendations! Published in 2021 at "Marine Drugs"
DOI: 10.3390/md19060311
Abstract: Peptides have a three-dimensional configuration that can adopt particular conformations for binding to proteins, which are well suited to interact with larger contact surface areas on target proteins. However, low cell permeability is a major… read more here.
Keywords: permeability cyclic; methylation; backbone methylation; methylation useful ... See more keywords