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Published in 2021 at "Journal of chemical information and modeling"
DOI: 10.1021/acs.jcim.0c00803
Abstract: Cyclic peptides have the potential to bind to challenging targets, which are undruggable with small molecules, but their application is limited by low membrane permeability. Here, using a series of cyclic pentapeptides, we showed that…
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Keywords:
permeability cyclic;
membrane permeability;
permeability;
peptides modulated ... See more keywords
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Published in 2021 at "Marine Drugs"
DOI: 10.3390/md19060311
Abstract: Peptides have a three-dimensional configuration that can adopt particular conformations for binding to proteins, which are well suited to interact with larger contact surface areas on target proteins. However, low cell permeability is a major…
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Keywords:
permeability cyclic;
methylation;
backbone methylation;
methylation useful ... See more keywords