Revisiting the Solubility–Permeability Relationship with Hydrophobic Drug Umifenovir in Pluronic Solutions: Impact of pH and Co-Solvent
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DOI: 10.3390/pharmaceutics15020422
Abstract: This study describes the influence of pluronic F-127 (F-127) and ethanol (EtOH) on the solubility of umifenovir (UMF) in buffer solutions of pH 2.0 and pH 7.4, and its permeability through cellulose membranes. A 44.4-fold… read more here.
Keywords: revisiting solubility; 127 micelles; permeability relationship; solubility ... See more keywords