F‐ATP synthase and the permeability transition pore: fewer doubts, more certainties
Sign Up to like & getrecommendations! Published in 2019 at "FEBS Letters"
DOI: 10.1002/1873-3468.13485
Abstract: Whether the mitochondrial permeability transition pore (PTP), also called mitochondrial megachannel (MMC), originates from the F‐ATP synthase is a matter of controversy. This hypothesis is supported both by site‐directed mutagenesis of specific residues of F‐ATP… read more here.
Keywords: permeability transition; atp synthase; transition pore;
Sevoflurane postconditioning improves spatial learning and memory ability involving mitochondrial permeability transition pore in hemorrhagic shock and resuscitation rats
Sign Up to like & getrecommendations! Published in 2019 at "Brain and Behavior"
DOI: 10.1002/brb3.1501
Abstract: Hemorrhagic shock induces the cognitive deficiency. Sevoflurane postconditioning has been documented to provide neuroprotection against ischemic–reperfusion injury by suppressing apoptosis. Mitochondrial permeability transition pore (mPTP) plays an important role in apoptosis, but it is unknown… read more here.
Keywords: sevoflurane postconditioning; hemorrhagic shock; mitochondrial permeability; transition pore ... See more keywords
Pharmacology of mitochondrial permeability transition pore inhibitors
Sign Up to like & getrecommendations! Published in 2019 at "Drug Development Research"
DOI: 10.1002/ddr.21593
Abstract: It is now firmly established that an important event in the formation of reperfusion injury of the heart is the opening of mitochondrial permeability transition pores (mPTPs), which changes the permeability of the mitochondria. mPTP… read more here.
Keywords: mptp; permeability; pharmacology; mitochondrial permeability ... See more keywords
Alleviation by GABAB Receptors of Neurotoxicity Mediated by Mitochondrial Permeability Transition Pore in Cultured Murine Cortical Neurons Exposed to N-Methyl-d-aspartate
Sign Up to like & getrecommendations! Published in 2017 at "Neurochemical Research"
DOI: 10.1007/s11064-017-2311-z
Abstract: Mitochondrial permeability transition pore (PTP) is supposed to at least in part participate in molecular mechanisms underlying the neurotoxicity seen after overactivation of N-methyl-d-aspartate (NMDA) receptor (NMDAR) in neurons. In this study, we have evaluated… read more here.
Keywords: methyl aspartate; nmda; neurotoxicity; mitochondrial permeability ... See more keywords
Ultrafine Particulate Matter Increases Cardiac Ischemia/Reperfusion Injury via Mitochondrial Permeability Transition Pore
Sign Up to like & getrecommendations! Published in 2017 at "Cardiovascular Toxicology"
DOI: 10.1007/s12012-017-9402-6
Abstract: Ultrafine particulate matter (UFP) has been associated with increased cardiovascular morbidity and mortality. However, the mechanisms that drive PM-associated cardiovascular disease and dysfunction remain unclear. We examined the impact of oropharyngeal aspiration of 100 μg UFP… read more here.
Keywords: mitochondrial permeability; injury; ultrafine particulate; permeability transition ... See more keywords
Phenylglyoxal inhibition of the mitochondrial F1FO-ATPase activated by Mg2+ or by Ca2+ provides clues on the mitochondrial permeability transition pore.
Sign Up to like & getrecommendations! Published in 2020 at "Archives of biochemistry and biophysics"
DOI: 10.1016/j.abb.2020.108258
Abstract: Phenylglyoxal (PGO), known to cause post-translational modifications of Arg residues, was used to highlight the role of arginine residues of the F1FO-ATPase, which may be crucial to yield the mitochondrial permeability transition pore (mPTP). In… read more here.
Keywords: f1fo atpase; atpase; ca2; mitochondrial permeability ... See more keywords
Channel formation by F-ATP synthase and the permeability transition pore: an update
Sign Up to like & getrecommendations! Published in 2018 at "Current Opinion in Physiology"
DOI: 10.1016/j.cophys.2017.12.006
Abstract: Abstract The most recent hypothesis about the nature of the mitochondrial permeability transition is that it forms after a Ca2+-dependent conformational change of the F1FO (F)-ATP synthase. This conformational change would lead to opening of… read more here.
Keywords: permeability transition; atp synthase; pore; transition ... See more keywords
Cyclophilin D regulation of the mitochondrial permeability transition pore.
Sign Up to like & getrecommendations! Published in 2022 at "Current opinion in physiology"
DOI: 10.1016/j.cophys.2022.100486
Abstract: The opening of the mitochondrial permeability transition pore (PTP) has been proposed to play a critical role in activating cell death in many settings, including cardiac ischemia and reperfusion. Although the identity of pore forming… read more here.
Keywords: ptp; transition pore; mitochondrial permeability; permeability transition ... See more keywords
Indium (III) induces isolated mitochondrial permeability transition by inhibiting proton influx and triggering oxidative stress.
Sign Up to like & getrecommendations! Published in 2017 at "Journal of inorganic biochemistry"
DOI: 10.1016/j.jinorgbio.2017.08.012
Abstract: While Indium's toxicity to organs is realized, its effects on mitochondria are still under investigation. Mitochondrial permeability transition (MPT) is widely accepted in mitochondrial dysfunction approaches and its importance in metal-induced mitochondrial degradation has been… read more here.
Keywords: permeability; inhibiting proton; mitochondrial permeability; membrane ... See more keywords
Sirtuin 3 and mitochondrial permeability transition pore (mPTP): a systematic review.
Sign Up to like & getrecommendations! Published in 2022 at "Mitochondrion"
DOI: 10.1016/j.mito.2022.03.004
Abstract: Mitochondrial permeability transition pore (mPTP) is a channel that opens at the inner mitochondrial membrane under conditions of stress. Sirtuin 3 (Sirt3) is a mitochondrial deacetylase known to play a major role in stress resistance… read more here.
Keywords: review; transition pore; sirt3; mitochondrial permeability ... See more keywords
Mitochondrial permeability transition pore in sea urchin female gametes
Sign Up to like & getrecommendations! Published in 2018 at "Mechanisms of development"
DOI: 10.1016/j.mod.2018.07.008
Abstract: Mitochondrial permeability transition pore (MPTP) has been associated to calcium homeostasis and reactive oxygen species (ROS) generation in several cell types. While extensively investigated in somatic cells, there are few data regarding MPTP phenomenon in… read more here.
Keywords: urchin female; sea; sea urchin; mitochondrial permeability ... See more keywords