ACOD1-mediated lysosomal membrane permeabilization contributes to Mycobacterium tuberculosis–induced macrophage death
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DOI: 10.1073/pnas.2425309122
Abstract: Significance Here, we show that when Mtb induces macrophages to express interferon-β (IFN-β), they overexpress an enzyme called ACOD1 normally found in mitochondria, whose product, itaconate, protects the cells. Surprisingly, that protective effect is overwhelmed… read more here.
Keywords: membrane permeabilization; lysosomal membrane; permeabilization contributes; mediated lysosomal ... See more keywords