Cell-Permeable Bicyclic Peptidyl Inhibitors against NEMO-IκB Kinase Interaction Directly from a Combinatorial Library.
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DOI: 10.1021/jacs.8b06738
Abstract: Macrocyclic peptides are capable of binding to flat protein surfaces such as the interfaces of protein-protein interactions with antibody-like affinity and specificity, but generally lack cell permeability in order to access intracellular targets. In this… read more here.
Keywords: permeable bicyclic; cell permeable; kinase; combinatorial library ... See more keywords